Evidence map›Paper›PMID 27798130›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016

Mechanisms of CO2/H+ Sensitivity of Astrocytes.

Egor Turovsky, Shefeeq M Theparambil, Vitaliy Kasymov, Joachim W Deitmer, Ana Gutierrez Del Arroyo, Gareth L Ackland, Jason J Corneveaux, April N Allen, Matthew J Huentelman, Sergey Kasparov and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.

  1. CONature communications · 2022
    Pooled it
  2. Review
  3. Article
  4. Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic-Like Behaviors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Kir4.1 channels contribute to astrocyte COCommunications biology · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Whole-brain analysis of CObioRxiv : the preprint server for biology · 2023
    Article
  16. Article
  17. The astrocytic NaThe Journal of physiology · 2023
    Article
  18. Relationships among biochemical measures in children with diabetic ketoacidosis.Journal of pediatric endocrinology & metabolism : JPEM · 2023
    Article
  19. Review
  20. Review

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Egor TurovskyCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom.
Shefeeq M TheparambilAbteilung für Allgemeine Zoologie, Fachbereich Biologie, University of Kaiserslautern, D 67663 Kaiserslautern, Germany.
Vitaliy KasymovCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom.ORCID 0000-0001-9543-9259
Joachim W DeitmerAbteilung für Allgemeine Zoologie, Fachbereich Biologie, University of Kaiserslautern, D 67663 Kaiserslautern, Germany.
Ana Gutierrez Del ArroyoWilliam Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom.ORCID 0000-0003-1240-4654
Gareth L AcklandWilliam Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom.
Jason J CorneveauxNeurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona 85004, and.
April N AllenNeurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona 85004, and.
Matthew J HuentelmanNeurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona 85004, and.
Sergey KasparovSchool of Physiology & Pharmacology, University of Bristol, Bristol BS8 1TH, United Kingdom.
Nephtali MarinaCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom.
Alexander V GourineCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom, a.gourine@ucl.ac.uk.
Translational Genomics Research Institute · USUniversity College London · GBQueen Mary University of London · GBUniversity of Kaiserslautern · DEInstitute of Cell Biophysics · RUUniversity of Bristol · GB

Funding

British Heart Foundation FS/13/5/29927Medical Research Council 42450Wellcome Trust 095064Wellcome Trust 200893Wellcome Trust 200893/Z/16/Z
6 · The paper itself

Abstract

Ventral regions of the medulla oblongata of the brainstem are populated by astrocytes sensitive to physiological changes in P SIGNIFICANCE STATEMENT: Brainstem astrocytes detect physiological changes in pH, activate neurons of the neighboring respiratory network, and contribute to the development of adaptive respiratory responses to the increases in the level of blood and brain P

Indexed as

Adenosine TriphosphateAnimalsAstrocytesBicarbonatesCalcium SignalingCarbon DioxideExocytosisHydrogenHydrogen-Ion ConcentrationIn Vitro TechniquesNeurogliaRatsRespirationSignal TransductionSodiumSodium-Bicarbonate SymportersAdenosine TriphosphateBicarbonatesCarbon DioxideHydrogenSlc4a4 protein, ratSodiumSodium-Bicarbonate SymportersSodium-Calcium Exchangersodium-calcium exchanger 1acidosisbrainstembreathingchemosensitivityhypercapniarespiration

Identifiers

PMID27798130
PMCPMC5083006
OpenAlexW2534809581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.