Evidence map›Paper›PMID 27798125›Full record

ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2016

Reconnecting Eye to Brain.

Michael C Crair, Carol A Mason

Abstract readReview
In one paragraph

Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Cerebral Amyloid Deposition WithHuman brain mapping · 2025
    Article
  6. Nanotherapy for Neural Retinal Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Axon guidance in regeneration of the mature central.Neural regeneration research · 2023
    Article
  16. OPA1 Dominant Optic Atrophy: Pathogenesis and Therapeutic Targets.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2023
    Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael C CrairDepartments of Neuroscience and Ophthalmology & Visual Science, Yale University, New Haven, Connecticut 06520, and michael.crair@yale.edu cam4@columbia.edu.
Carol A MasonDepartments of Pathology and Cell Biology, Neuroscience, and Ophthalmology, Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York 10032 michael.crair@yale.edu cam4@columbia.edu.ORCID 0000-0001-6253-505X

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Mechanisms of Visual Map Development in the Thalamus and Superior ColliculusR01EY015788 · NEI · YALE UNIVERSITY · PI Michael C. Crair · 2005 to 2026
$7.9M
The Role of Zic Genes in Patterning the Binocular ProjectionR01EY015290 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MASON, CAROL A. · 2004 to 2023
$7.6M
Yale Core Grant for Vision ResearchP30EY026878 · NEI · YALE UNIVERSITY · PI In-Jung Kim · 2016 to 2026
$7.1M
GROWTH AND GUIDANCE OF RETINAL AXONSR01EY012736 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MASON, CAROL A. · 1999 to 2017
$6.4M
In Vivo Properties of Spontaneous Waves in the Retina and Developing Visual SysteR01EY023105 · NEI · YALE UNIVERSITY · PI CRAIR, MICHAEL C. · 2013 to 2017
$2.1M
NCATS NIH HHS UL1 TR001863NEI NIH HHS P30 EY026878NEI NIH HHS R01 EY012736NEI NIH HHS R01 EY015290NEI NIH HHS R01 EY015788NEI NIH HHS R01 EY023105
6 · The paper itself

Abstract

Although much is known about the regenerative capacity of retinal ganglion cells, very significant barriers remain in our ability to restore visual function following traumatic injury or disease-induced degeneration. Here we summarize our current understanding of the factors regulating axon guidance and target engagement in regenerating axons, and review the state of the field of neural regeneration, focusing on the visual system and highlighting studies using other model systems that can inform analysis of visual system regeneration. This overview is motivated by a Society for Neuroscience Satellite meeting, "Reconnecting Neurons in the Visual System," held in October 2015 sponsored by the National Eye Institute as part of their "Audacious Goals Initiative" and co-organized by Carol Mason (Columbia University) and Michael Crair (Yale University). The collective wisdom of the conference participants pointed to important gaps in our knowledge and barriers to progress in promoting the restoration of visual system function. This article is thus a summary of our existing understanding of visual system regeneration and provides a blueprint for future progress in the field.

Indexed as

Ocular Physiological PhenomenaAnimalsAxonsBrainHumansOptic NerveRetinal Ganglion CellsVisual Pathwaysaxonaxon guidanceaxon regenerationeyelateral geniculate nucleusoptic nerveregenerationretinaretinal ganglion cellssuperior colliculustraumatic brain injuryvisionvisual cortex

Identifiers

PMID27798125
PMCPMC5083002

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.