ArticleHuman molecular genetics2016
Population structure of Han Chinese in the modern Taiwanese population based on 10,000 participants in the Taiwan Biobank project.
Article in Human molecular genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 222 papers, 3 of them syntheses that pooled it.
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Who cites it
222 citing papers in PubMed, 3 syntheses or guidelines pooled it, 280 citations in OpenAlex.
- Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan.Nature communications · 2024Pooled it
- Genome-wide association study of age at menarche in the Taiwan Biobank suggests NOL4 as a novel associated gene.Journal of human genetics · 2023Pooled it
- Multi-omics analysis identifies CpGs near G6PC2 mediating the effects of genetic variants on fasting glucose.Diabetologia · 2021Pooled it
- Migraines and the association of cognitive impairment: a one- and two-sample mendelian randomization analysis.Dialogues in clinical neuroscience · 2026Article
- Arrhythmia and cardiomyopathy risk in Taiwan with complementary biobank evidence on thyroid genetic susceptibility: an integrative population-based framework.Endocrine connections · 2026Article
- Genetic evidence for the associations of sleep patterns with cognitive function in older adults: insights from polygenic scores in the Taiwan biobank.European archives of psychiatry and clinical neuroscience · 2026Article
- Effect ofBJPsych open · 2026Article
- Genome-wide association and polygenic risk score analyses of MASLD-related hepatic steatosis severity in a Taiwanese Han population.Cell & bioscience · 2026Article
- Smoking, Alcohol Use, and Low Back Pain: A Large-Scale Study Identifying a Synergistic Lifestyle Risk.Global spine journal · 2026Article
- Bidirectional Mendelian randomization of leukocyte counts, renal function, and Lipocalin-2 Levels: disentangling the genetic links, causal pathways and cardiovascular outcomes.Journal of human genetics · 2026Article
- Article
- Familial coaggregation and shared genetic loading of mental disorders and cardiovascular diseases.Psychological medicine · 2026Article
- Genome-wide association and population-tailored polygenic risk for Parkinson's disease in Taiwan.NPJ Parkinson's disease · 2026Article
- Genomic landscape and fine-scale population structure of Helicobacter pylori across China.Biomarker research · 2026Article
- Habitual Tea Consumption Is Associated with a Low Prevalence of Self-Reported Lifetime History of Depression in Taiwanese Population Study.Nutrients · 2026Article
- Comparative polygenic predispositions of treatment-resistant depression in East Asian and European populations.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Associations Between Coffee Consumption and the Prevalence of Metabolic Syndrome: A Nationwide Cross-Sectional Survey of Taiwanese Adults.Nutrients · 2026Observational
- Polygenic risk and air pollution trends in relation to type 2 diabetes: evidence from the Taiwan Biobank.Diabetology & metabolic syndrome · 2026Article
- Genetic Perspective on the Relationship between Female Reproductive Traits, Exercise, and Bone Health Outcomes: Evidence from a National Database.Lifestyle genomics · 2026Article
- Opposite Association Between Wet-Bulb Globe Temperature With Central Obesity in Different Geographic Regions in Taiwan.International journal of endocrinology · 2026Article
162 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
The Taiwan Biobank (TWB) aims to build a nationwide research database that integrates genomic/epigenomic profiles, lifestyle patterns, dietary habits, environmental exposure history and long-term health outcomes of 300,000 residents of Taiwan. We describe here an investigation of the population structure of Han Chinese on this Pacific island using genotype data of 591,048 SNPs in an initial freeze of 10,801 unrelated TWB participants. In addition to the North-South cline reported in other Han Chinese populations, we find the Taiwanese Han Chinese clustered into three cline groups: 5% were of northern Han Chinese ancestry, 79.9% were of southern Han Chinese ancestry, and 14.5% belonged to a third (T) group. We also find that this T group is genetically distinct from neighbouring Southeast Asians and Austronesian tribes but similar to other southern Han Chinese. Interestingly, high degree of LD between HLA haplotype A*33:03-B*58:01, an MHC allele being of pathological relevance, and SNPs across the MHC region was observed in subjects with T origin, but not in other Han Chinese. This suggested the T group individuals may have experienced evolutionary events independent from the other southern Han Chinese. Based on the newly-discovered population structure, we detect different loci susceptible to type II diabetes in individuals with southern and northern Han Chinese ancestries. Finally, as one of the largest dataset currently available for the Chinese population, genome-wide statistics for the 10,810 subjects are made publicly accessible through Taiwan View (https://taiwanview.twbiobank.org.tw/index; date last accessed October 14, 2016) to encourage future genetic research and collaborations with the island Taiwan.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.