ArticleHuman molecular genetics2016
Variants in angiopoietin-2 (ANGPT2) contribute to variation in nocturnal oxyhaemoglobin saturation level.
Article in Human molecular genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Circulating angiopoietin-2 and the risk of mortality in patients with acute respiratory distress syndrome: a systematic review and meta-analysis of 10 prospective cohort studies.Therapeutic advances in respiratory diseasePooled it
- Changes in cerebral oxygenation and cerebral blood flow during hemodialysis - A simultaneous near-infrared spectroscopy and positron emission tomography study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Trial
- Striatal Dysregulation of Angpt2 and Circadian Gene Expression in a Rotenone Rat Model of Parkinson's Disease.Journal of molecular neuroscience : MN · 2026Article
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- Sex andJournal of neurophysiology · 2024Article
- Genetics of circadian rhythms and sleep in human health and disease.Nature reviews. Genetics · 2023Review
- Targeted Genome Sequencing Identifies Multiple Rare Variants in Caveolin-1 Associated with Obstructive Sleep Apnea.American journal of respiratory and critical care medicine · 2022Article
- Effect of positive airway pressure therapy of obstructive sleep apnea on circulating Angiopoietin-2.Sleep medicine · 2022Article
- Article
- Complement promotes endothelial von Willebrand factor and angiopoietin-2 release in obstructive sleep apnea.Sleep · 2021Article
- Angiopoietin-2 gene polymorphisms are biomarkers for the development and progression of colorectal cancer in Han Chinese.International journal of medical sciences · 2020Article
- Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level.American journal of human genetics · 2019Article
- More Than the Sum of the Respiratory Events: Personalized Medicine Approaches for Obstructive Sleep Apnea.American journal of respiratory and critical care medicine · 2019Review
- GenePy - a score for estimating gene pathogenicity in individuals using next-generation sequencing data.BMC bioinformatics · 2019Article
- Identifying Rare Variant Associations in Admixed Populations.Scientific reports · 2019Article
- Combined linkage and association analysis identifies rare and low frequency variants for blood pressure at 1q31.European journal of human genetics : EJHG · 2019Article
- Correlations between angiopoietin-2 gene polymorphisms and lung cancer progression in a Chinese Han population.Journal of Cancer · 2019Article
- The genetics of obstructive sleep apnoea.Respirology (Carlton, Vic.) · 2018Review
- Update in Sleep-disordered Breathing 2016.American journal of respiratory and critical care medicine · 2017Review
- Association between Obstructive Sleep Apnea and Exfoliation Syndrome: The Utah Project on Exfoliation Syndrome.Ophthalmology. GlaucomaArticle
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Authors and funding
23 authors at 13 institutions in 1 country.
Funding
Abstract
Genetic determinants of sleep-disordered breathing (SDB), a common set of disorders that contribute to significant cardiovascular and neuropsychiatric morbidity, are not clear. Overnight nocturnal oxygen saturation (SaO2) is a clinically relevant and easily measured indicator of SDB severity but its genetic contribution has never been studied. Our recent study suggests nocturnal SaO2 is heritable. We performed linkage analysis, association analysis and haplotype analysis of average nocturnal oxyhaemoglobin saturation in participants in the Cleveland Family Study (CFS), followed by gene-based association and additional tests in four independent samples. Linkage analysis identified a peak (LOD = 4.29) on chromosome 8p23. Follow-up association analysis identified two haplotypes in angiopoietin-2 (ANGPT2) that significantly contributed to the variation of SaO2 (P = 8 × 10-5) and accounted for a portion of the linkage evidence. Gene-based association analysis replicated the association of ANGPT2 and nocturnal SaO2. A rare missense SNP rs200291021 in ANGPT2 was associated with serum angiopoietin-2 level (P = 1.29 × 10-4), which was associated with SaO2 (P = 0.002). Our study provides the first evidence for the association of ANGPT2, a gene previously implicated in acute lung injury syndromes, with nocturnal SaO2, suggesting that this gene has a broad range of effects on gas exchange, including influencing oxygenation during sleep.
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