ArticleBMJ open2016
Cohort profile: the Baependi Heart Study-a family-based, highly admixed cohort study in a rural Brazilian town.
Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Early chronotype with advanced activity rhythms and dim light melatonin onset in a rural population.Journal of pineal research · 2020Trial
- The Role of Obesity in the Association Between Alcohol Consumption and HDL-c Levels: Baependi Heart Study.Lipids · 2026Article
- External Validation and Local Adaptation of Estimated Pulse Wave Velocity Models in a Brazilian Population.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Sex-Specific Impact of Metabolic Syndrome on Brain Structures Vulnerable to Alzheimer's Disease: A Cross-Sectional Study in a Brazilian Cohort.Brain sciences · 2025Article
- Blood pressure-independent progression of arterial stiffness in older adults.Journal of human hypertension · 2025Article
- BMI, Sleep Architecture, and Glucose Metabolism: Insights From the Baependi Heart Study.Obesity (Silver Spring, Md.) · 2025Observational
- Heritability of sleep architecture based on home polysomnography.Journal of sleep research · 2025Article
- Article
- Assessing the predictive efficacy of European-based systolic blood pressure polygenic risk scores in diverse Brazilian cohorts.Scientific reports · 2024Article
- Effects of glycaemic control on memory performance, hippocampal volumes and depressive symptomology.Diabetology & metabolic syndrome · 2024Article
- Altered sleep architecture in diabetes and prediabetes: findings from the Baependi Heart Study.Sleep · 2024Article
- A pedigree-based cohort to study the genetic risk factors for cardiometabolic diseases: study design, baseline characteristics and preliminary results.Frontiers in public health · 2023Article
- Genome-wide analyses identifyiScience · 2022Article
- Depression, religiosity, and telomere length in the Study on Stress, Spirituality, and Health (SSSH).International journal of mental health and addiction · 2022Article
- Comparing different metabolic indexes to predict type 2 diabetes mellitus in a five years follow-up cohort: The Baependi Heart Study.PloS one · 2022Article
- Compared Heritability of Chronotype Instruments in a Single Population Sample.Journal of biological rhythms · 2021Article
- Evening preference correlates with regional brain volumes in the anterior occipital lobe.Chronobiology international · 2021Article
- Triglyceride glucose index as a tool to motivate early lifestyle modification in young adults at diabetes risk: The Baependi Heart Study.Preventive medicine reports · 2020Article
- Age and Sex Differences in Heart Rate Variability and Vagal Specific Patterns - Baependi Heart Study.Global heart · 2020Article
- Roadmap for Establishing Large-Scale Genomic Medicine Initiatives in Low- and Middle-Income Countries.American journal of human genetics · 2020Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCardiovascular disease (CVD) is a major challenge to global health. The same epidemiological transition scenario is replayed as countries develop, but with variations based on environment, culture and ethnic mixture. The Baependi Heart Study was set up in 2005 to develop a longitudinal family-based cohort study that reflects on some of the genetic and lifestyle-related peculiarities of the Brazilian populations, in order to evaluate genetic and environmental influences on CVD risk factor traits.
participantsProbands were recruited in Baependi, a small rural town in the state of Minas Gerais, Brazil, following by first-degree and then increasingly more distant relatives. The first follow-up wave took place in 2010, and the second in 2016. At baseline, the study evaluated 1691 individuals across 95 families. Cross-sectional data have been collected for 2239 participants. FINDINGS TO DATE: Environmental and lifestyle factors and measures relevant to cardiovascular health have been reported. Having expanded beyond cardiovascular health outcomes, the phenotype datasets now include genetics, biochemistry, anthropometry, mental health, sleep and circadian rhythms. Many of these have yielded heritability estimates, and a shared genetic background of anxiety and depression has recently been published. In spite of universal access to electricity, the population has been found to be strongly shifted towards morningness compared with metropolitan areas. FUTURE PLANS: A new follow-up, marking 10 years of the study, is ongoing in 2016, in which data are collected as in 2010 (with the exception of the neuropsychiatric protocol). In addition to this, a novel questionnaire package collecting information about intelligence, personality and spirituality is being planned. The data set on circadian rhythms and sleep will be amended through additional questionnaires, actimetry, home sleep EEG recording and dim light melatonin onset (DLMO) analysis. Finally, the anthropometric measures will be expanded by adding three-dimensional facial photography, voice recording and anatomical brain MRI.
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