Evidence map›Paper›PMID 27797988›Full record

ArticleBMJ open2016

Cross-sectional and longitudinal study protocols of the 'ADIposity and BOne metabolism: effects of eXercise-induced weight loss in obese adolescents' (ADIBOX) project.

Elodie Chaplais, Frédéric Dutheil, Geraldine Naughton, David Greene, Bruno Pereira, David Thivel, Daniel Courteix

Registry-linked trialAbstract read
In one paragraph

Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02626273 (ADIposity and Bone Metabolism), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02626273 naunknown statusnot on this map

ADIposity and Bone Metabolism: Effects of eXercise-induced Weight Loss in Obese Adolescents

TypeinterventionalSponsorUniversity Hospital, Clermont-FerrandRan2015 to 2016Enrolled50ConditionsObesityArmsweight loss
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elodie ChaplaisLaboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), Clermont University, Blaise Pascal University, Clermont-Ferrand, France.
Frédéric DutheilLaboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), Clermont University, Blaise Pascal University, Clermont-Ferrand, France.ORCID 0000-0002-1468-6029
Geraldine NaughtonSchool of Exercise Science, Australian Catholic University, Strathfield, New South Wales, Australia.
David GreeneSchool of Exercise Science, Australian Catholic University, Strathfield, New South Wales, Australia.
Bruno PereiraBiostatistics Unit (DRCI), University Hospital CHU G. Montpied, Clermont-Ferrand, France.
David ThivelLaboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), Clermont University, Blaise Pascal University, Clermont-Ferrand, France.
Daniel CourteixLaboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), Clermont University, Blaise Pascal University, Clermont-Ferrand, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionA need exists for sustainable and clinically effective weight management interventions, suitable for preventing well-linked chronic disease such as diabetes and cardiovascular disease and some less investigated secondary conditions such as bone alteration. The ADIposity and BOne metabolism: effects of eXercise-induced weight loss in obese adolescents (ADIBOX) protocol was designed to provide a better understanding of the interaction between adipokines and bone hormones in adolescents with obesity and how a 10-month physical activity programme may affect these interactions. METHODS AND ANALYSIS: The ADIBOX protocol combines 2 studies. The first study involves a total of 68 adolescents aged 12-16 years. This cross-sectional study will include both males and females (1:1 ratio), either living with obesity/overweight (n=34; body mass index (BMI) ≤97th centile and ≥85th centile) or normal weight (n=34; BMI<85th centile). The second study is a longitudinal study that will include 50 obese adolescent girls and track them over a period of 42 weeks. Weight loss programme will consist of a combination of physical activity and a normocaloric diet. Bone and adiposity-related measurements will be performed every 14 weeks. Both studies will assess participants' anthropometric profile, nutrition and physical activity, body composition, bone densitometry and blood markers of bone, growth and adiposity. ETHICS AND DISSEMINATION: The ADIBOX protocol complies with the ethics guidelines for clinical research and has been approved by their respective ethics committee (Australian Catholic University Committee Ethic, Australia and Hospital Sud Est 1 committee, France). Findings from this protocol are expected to clarify the possible interactions between adiposity and bone in childhood obesity and will be disseminated at several research conferences and published articles in peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT02626273; Pre-results.

Indexed as

AdiposityAdolescentAustraliaBody CompositionBone DevelopmentCross-Sectional StudiesFemaleGene Expression Regulation, DevelopmentalGrowth PlateHumansLongitudinal StudiesMalePediatric ObesityProgram EvaluationWeight LossWeight Reduction Programsadipocytesadolescentsobesityosteocytesphysical activity

Identifiers

PMID27797988
PMCPMC5073595

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.