ArticleDiabetes care2016
Tangled Up in Blue: Unraveling the Links Between Emotional Distress and Treatment Adherence in Type 2 Diabetes.
Article in Diabetes care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 75 citations in OpenAlex.
- Differential associations of somatic and cognitive-affective symptoms of depression with inflammation and insulin resistance: cross-sectional and longitudinal results from the Emotional Distress Sub-Study of the GRADE study.Diabetologia · 2025 · on this mapTrial
- Emotional Distress Predicts Reduced Type 2 Diabetes Treatment Adherence in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).Diabetes care · 2024 · on this mapTrial
- Distress and Type 2 Diabetes Self-Care: Putting the Pieces Together.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2021Trial
- Temporal dynamics of daily diabetes-specific burdens using intensive longitudinal data: the central role of feelings of guilt within a multilevel network analysis.Diabetologia · 2026Article
- mHealth Low-Carbohydrate Type 2 Diabetes Intervention Positively Impacts Sleep Quality and Psychosocial Outcomes.International journal of behavioral medicine · 2026Article
- The Impact of the Multidisciplinary Team on Medication Adherence in Type 2 Diabetes: A Narrative Review.Journal of multidisciplinary healthcare · 2026Review
- Associations Between Suboptimal Social Determinants of Health and Diabetes Distress in Low-Income Patients on Medicaid.Journal of general internal medicine · 2025Article
- The interface of depression and diabetes: treatment considerations.Translational psychiatry · 2025Review
- The Impact of Psychological Stress on Wound Healing: Implications for Neocollagenesis and Scar Treatment Efficacy.Clinical, cosmetic and investigational dermatology · 2025Review
- Observational
- Patient-centered care in diabetes care-concepts, relationships and practice.World journal of diabetes · 2024Review
- Diabetes causal attributions: Pathways to stigma and health.Stigma and health · 2024Article
- Recurrent depression relates to worse outcomes than single episode depression among Hispanic adolescents with diabetes.Health psychology report · 2024Article
- The Clinical Relevance of Diabetes Distress versus Major Depression in Type 2 Diabetes: A Latent Class Analysis from the Fremantle Diabetes Study Phase II.Journal of clinical medicine · 2023Article
- Influence of depression on racial and ethnic disparities in diabetes control.BMJ open diabetes research & care · 2023Article
- Understanding Alveolar echinococcosis patients' psychosocial burden and coping strategies-A qualitative interview study.PLoS neglected tropical diseases · 2023Article
- The influence of weight on psychosocial well-being in diabetes.BMC psychology · 2023Article
- Factors Associated With Diabetes Distress Among Patients With Poorly Controlled Type 2 Diabetes.Journal of the Endocrine Society · 2023Article
- Emotional distress, self-management, and glycemic control among participants enrolled in the glycemia reduction approaches in diabetes: A comparative effectiveness (GRADE) study.Diabetes research and clinical practice · 2023 · on this mapArticle
- Memory complaints moderate the concordance between self-report and electronically monitored adherence in adults with type 2 diabetes.Journal of diabetes and its complications · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe conducted comprehensive assessments of emotional distress to examine relations with diabetes medication adherence over time. RESEARCH DESIGN AND
methodsEthnically and socioeconomically diverse adults treated for type 2 diabetes completed validated self-reports (SRs) for diabetes distress and depression, were administered semistructured depression interviews, and provided blood samples for A1C. Medication adherence among 104 participants was electronically monitored (EM) over the subsequent 3 months; validated SRs of medication adherence were also obtained. Hierarchical linear regression evaluated independent effects of diabetes distress and depression on adherence.
resultsMean ± SD 3-month medication adherence was 76.1% ± 25.7% for EM and 83.7% ± 21.9% for SR. Higher levels of SR (P < 0.001) and interview-based (P < 0.05) depressive symptom severity (P < 0.05) and diabetes-related distress (P < 0.01) showed a significant bivariate association with EM and SR nonadherence. Regression models showed baseline diabetes distress was a significant independent predictor of EM (β = -0.29; P = 0.001) and SR adherence (β = -0.24; P < 0.02) at follow-up. SR depression was an independent predictor of EM and SR adherence and reduced the effects of diabetes distress to nonsignificance. Subsequent models indicated this effect was driven by somatic rather than cognitive-affective symptoms of depression. Results were consistent but weaker for interview-based depressive symptoms.
conclusionsFindings support diabetes-related distress and depression symptom severity as risk factors for type 2 diabetes medication nonadherence. Somatic symptoms captured by depression measures, but not cognitive-affective symptoms, independently predict nonadherence and should be further investigated as a potential link between emotional distress and nonadherence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.