ArticleCarcinogenesis2016
A genome-wide analysis of gene-caffeine consumption interaction on basal cell carcinoma.
Xin Li, Marilyn C Cornelis, Liming Liang, Fengju Song, Immaculata De Vivo, Edward Giovannucci, Jean Y Tang, Jiali Han
Open access · bronzeAbstract read
In one paragraphArticle in Carcinogenesis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
0.3field-weighted citation impact, top 28% of its field
What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors at 6 institutions in 2 countries.
Xin LiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA 02115, USA.
Marilyn C CornelisDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago IL 60611, USA.
Liming LiangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA 02115, USA.
Fengju SongDepartment of Epidemiology and Biostatistics, Tianjin Medical University Cancer Hospital and Institute, Tianjin 300060, China.
Immaculata De VivoDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA 02115, USA.
Edward GiovannucciDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA 02115, USA.
Jean Y TangDepartment of Dermatology, Stanford University School of Medicine, Redwood City, CA 94063, USA.
Jiali HanDepartment of Epidemiology, Fairbanks School of Public Health, Indiana University, Indianapolis, IN 46202, USA jialhan@iu.edu.
Harvard University · USBrigham and Women's Hospital · USIndiana University Health · USNorthwestern University · USStanford University · USTianjin Medical University Cancer Institute and Hospital · CN
Funding
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8MIndiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MCancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5MBIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3MGenome-Wide Gene-Caffeine Interactions on Risk of Skin Basal Cell Carcinoma2R03CA188568 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI HAN, JIALI · 2014 to 2015
$171kNCATS NIH HHS UL1 TR001108NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA049449NCI NIH HHS R03 CA188568NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107
6 · The paper itselfAbstract
Animal models have suggested that oral or topical administration of caffeine could inhibit ultraviolet-induced carcinogenesis via the ataxia telangiectasia and rad3 (ATR)-related apoptosis. Previous epidemiological studies have demonstrated that increased caffeine consumption is associated with reduced risk of basal cell carcinoma (BCC). To identify common genetic markers that may modify this association, we tested gene-caffeine intake interaction on BCC risk in a genome-wide analysis. We included 3383 BCC cases and 8528 controls of European ancestry from the Nurses' Health Study and Health Professionals Follow-up Study. Single nucleotide polymorphism (SNP) rs142310826 near the NEIL3 gene showed a genome-wide significant interaction with caffeine consumption (P = 1.78 × 10
Indexed as
AnimalsAtaxia Telangiectasia Mutated ProteinsBasal Cell CarcinomaCaffeineCarcinogenesisEpistasis, GeneticFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiceN-Glycosyl HydrolasesPolymorphism, Single NucleotideRisk FactorsSkin NeoplasmsAtaxia Telangiectasia Mutated ProteinsATR protein, humanCaffeineNEIL3 protein, humanN-Glycosyl Hydrolases
Identifiers
PMID27797824
PMCPMC5137266
OpenAlexW2529563084
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