ArticleNeuropsychology2016
The effectiveness and unique contribution of neuropsychological tests and the δ latent phenotype in the differential diagnosis of dementia in the uniform data set.
Article in Neuropsychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- The Differential Effects of Alzheimer's Disease and Lewy Body Pathology on Cognitive Performance: a Meta-analysis.Neuropsychology review · 2017Pooled it
- Biomarker affliction classes contribute additively to observed dementia severity and prospective conversion risk.Journal of Alzheimer's disease : JAD · 2026Article
- Can Frontal Assessment Battery Discriminate between Patients with Alzheimer's and Frontotemporal Dementia?Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- Comparing clinical features of behavioral variant frontotemporal dementia and Alzheimer's disease using network analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Affliction class moderates the dementing impact of adipokines.Neuropsychology · 2025Article
- Statin use moderates APOE's and CRP's associations with dementia and is associated with lesser dementia severity in ε4 carriers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
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- Intelligence, cognition, and major neurocognitive disorders: From constructs to measures.Cerebral circulation - cognition and behavior · 2023Article
- The effects of CNS atrophy and ICVD on tests of executive function and functional status are mediated by intelligence.Cerebral circulation - cognition and behavior · 2023Article
- New Insights and Knowledge on Cognition and Dementia from Population-Based Cohort of Older Adults in India.Journal of the American Geriatrics Society · 2020Article
- Online Clinical Consensus Diagnosis of Dementia: Development and Validation.Journal of the American Geriatrics Society · 2020Article
- Subjective Memory Complaints in White and African American Participants.Journal of geriatric psychiatry and neurology · 2020Article
- Serum Adiponectin is Related to Dementia.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Blood-based protein mediators of senility with replications across biofluids and cohorts.Brain communications · 2020Article
- Blood-based protein predictors of dementia severity as measured by δ: Replication across biofluids and cohorts.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- Article
- δ scores predict mild cognitive impairment and Alzheimer's disease conversions from nondemented states.Alzheimer's & dementia (Amsterdam, Netherlands) · 2017Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTwo main approaches to the interpretation of cognitive test performance have been utilized for the characterization of disease: evaluating shared variance across tests, as with measures of severity, and evaluating the unique variance across tests, as with pattern and error analysis. Both methods provide necessary information, but the unique contributions of each are rarely considered. This study compares the 2 approaches on their ability to differentially diagnose with accuracy, while controlling for the influence of other relevant demographic and risk variables.
methodArchival data requested from the NACC provided clinical diagnostic groups that were paired to 1 another through a genetic matching procedure. For each diagnostic pairing, 2 separate logistic regression models predicting clinical diagnosis were performed and compared on their predictive ability. The shared variance approach was represented through the latent phenotype δ, which served as the lone predictor in 1 set of models. The unique variance approach was represented through raw score values for the 12 neuropsychological test variables comprising δ, which served as the set of predictors in the second group of models.
resultsExamining the unique patterns of neuropsychological test performance across a battery of tests was the superior method of differentiating between competing diagnoses, and it accounted for 16-30% of the variance in diagnostic decision making.
conclusionImplications for clinical practice are discussed, including test selection and interpretation. (PsycINFO Database Record
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