Evidence map›Paper›PMID 27797517›Full record

ArticleJournal of medicinal chemistry2016

Structure-Activity Relationships of [des-Arg

Cyf N Ramos-Colon, Yeon Sun Lee, Michael Remesic, Sara M Hall, Justin LaVigne, Peg Davis, Alexander J Sandweiss, Mary I McIntosh, Jessica Hanson, Tally M Largent-Milnes and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Cyf N Ramos-ColonDepartment of Pharmacology and Toxicology, ‡Department of Chemistry and Biochemistry, and §Department of Pharmacology, University of Arizona , Tucson, Arizona 85721, United States.
Yeon Sun LeeDepartment of Pharmacology and Toxicology, ‡Department of Chemistry and Biochemistry, and §Department of Pharmacology, University of Arizona , Tucson, Arizona 85721, United States.
Michael RemesicDepartment of Pharmacology and Toxicology, ‡Department of Chemistry and Biochemistry, and §Department of Pharmacology, University of Arizona , Tucson, Arizona 85721, United States.
Sara M HallDepartment of Pharmacology and Toxicology, ‡Department of Chemistry and Biochemistry, and §Department of Pharmacology, University of Arizona , Tucson, Arizona 85721, United States.
Justin LaVigneDepartment of Pharmacology and Toxicology, ‡Department of Chemistry and Biochemistry, and §Department of Pharmacology, University of Arizona , Tucson, Arizona 85721, United States.
Peg DavisDepartment of Pharmacology and Toxicology, ‡Department of Chemistry and Biochemistry, and §Department of Pharmacology, University of Arizona , Tucson, Arizona 85721, United States.
Alexander J SandweissDepartment of Pharmacology and Toxicology, ‡Department of Chemistry and Biochemistry, and §Department of Pharmacology, University of Arizona , Tucson, Arizona 85721, United States.
Mary I McIntoshDepartment of Pharmacology and Toxicology, ‡Department of Chemistry and Biochemistry, and §Department of Pharmacology, University of Arizona , Tucson, Arizona 85721, United States.
Jessica HansonDepartment of Pharmacology and Toxicology, ‡Department of Chemistry and Biochemistry, and §Department of Pharmacology, University of Arizona , Tucson, Arizona 85721, United States.
Tally M Largent-MilnesDepartment of Pharmacology and Toxicology, ‡Department of Chemistry and Biochemistry, and §Department of Pharmacology, University of Arizona , Tucson, Arizona 85721, United States.
Todd W VanderahDepartment of Pharmacology and Toxicology, ‡Department of Chemistry and Biochemistry, and §Department of Pharmacology, University of Arizona , Tucson, Arizona 85721, United States.
John StreicherDepartment of Pharmacology and Toxicology, ‡Department of Chemistry and Biochemistry, and §Department of Pharmacology, University of Arizona , Tucson, Arizona 85721, United States.
Frank PorrecaDepartment of Pharmacology and Toxicology, ‡Department of Chemistry and Biochemistry, and §Department of Pharmacology, University of Arizona , Tucson, Arizona 85721, United States.
Victor J HrubyDepartment of Pharmacology and Toxicology, ‡Department of Chemistry and Biochemistry, and §Department of Pharmacology, University of Arizona , Tucson, Arizona 85721, United States.
University of Arizona · US

Funding

THERAPEUTIC PROFILES OF OPIOID DELTA RECEPTORS--NEW MODALITIESP01DA006284 · NIDA · UNIVERSITY OF ARIZONA · PI HRUBY, VICTOR J · 1989 to 2015
$14.8M
NOVEL NON-PEPTIDE OPIOID LIGANDS FOR PAINR01DA013449 · NIDA · UNIVERSITY OF ARIZONA · PI HRUBY, VICTOR J · 2000 to 2015
$6.8M
NIDA NIH HHS P01 DA006284NIDA NIH HHS R01 DA013449
6 · The paper itself

Abstract

Dynorphin A (Dyn A) is an endogenous ligand for the opioid receptors with preference for the κ opioid receptor (KOR), and its structure-activity relationship (SAR) has been extensively studied at the KOR to develop selective potent agonists and antagonists. Numerous SAR studies have revealed that the Arg

Indexed as

AnimalsCell LineCHO CellsCricetulusDose-Response Relationship, DrugDynorphinsGuinea PigsMaleMiceMice, Inbred ICRNarcotic AntagonistsPainRatsReceptors, Opioid, kappaStructure-Activity RelationshipDynorphinsNarcotic AntagonistsReceptors, Opioid, kappa

Identifiers

PMID27797517
PMCPMC5693303
OpenAlexW2545991002

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.