ArticleAnalytical chemistry2016
MOSAIC: A Modular Single-Molecule Analysis Interface for Decoding Multistate Nanopore Data.
Article in Analytical chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Microfluidic Sample Compartmentalization for Biomolecular Concentration Quantification Using a Nanopore Sensor.Small methods · 2026Article
- A universal deep learning framework for empowering nanopore identification by reinforcing temporal signals.Nature communications · 2026Article
- Nanopore event detection in a simple and adaptive way.bioRxiv : the preprint server for biology · 2026Article
- Digital Immunoassays for Sensitive Quantification of Blood Biomarkers Using Solid-State Nanopores.ACS nano · 2026Article
- Continuous, Low Latency Estimation of the Size and Shape of Single Proteins from Real-Time Nanopore Data.Analytical chemistry · 2026Article
- Single-Molecule Biodosimetry.Analytical chemistry · 2025Article
- Single-Molecule Protein Profiling Using Nanopores and Dimeric Aptamer-Modified DNA Carriers.Angewandte Chemie (International ed. in English) · 2025Article
- Nanopore sensing of protein and peptide conformation for point-of-care applications.Nature communications · 2025Review
- A Robust Parallel Computing Data Extraction Framework for Nanopore Experiments.Small methods · 2024Article
- Time-domain event detection using single-instruction, multiple-thread gpGPU architectures in single-molecule biophysical data.Computer physics communications · 2024Article
- Multiplexed detection of viral antigen and RNA using nanopore sensing and encoded molecular probes.Nature communications · 2023Article
- Analysis of Nanopore Data: Classification Strategies for an Unbiased Curation of Single-Molecule Events from DNA Nanostructures.ACS sensors · 2023Article
- Identification of tagged glycans with a protein nanopore.Nature communications · 2023Article
- Nanopore Discrimination of Coagulation Biomarker Derivatives and Characterization of a Post-Translational Modification.ACS central science · 2023Article
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- AutoNanopore: An Automated Adaptive and Robust Method to Locate Translocation Events in Solid-State Nanopore Current Traces.ACS omega · 2022Article
- A Generalized Transformer-Based Pulse Detection Algorithm.ACS sensors · 2022Article
- A Guide to Signal Processing Algorithms for Nanopore Sensors.ACS sensors · 2021Article
- Protein identification by nanopore peptide profiling.Nature communications · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Biological and solid-state nanometer-scale pores are the basis for numerous emerging analytical technologies for use in precision medicine. We developed Modular Single-Molecule Analysis Interface (MOSAIC), an open source analysis software that improves the accuracy and throughput of nanopore-based measurements. Two key algorithms are implemented: ADEPT, which uses a physical model of the nanopore system to characterize short-lived events that do not reach their steady-state current, and CUSUM+, a version of the cumulative sum statistical method optimized for longer events that do. We show that ADEPT detects previously unreported conductance states that occur as double-stranded DNA translocates through a 2.4 nm solid-state nanopore and reveals new interactions between short single-stranded DNA and the vestibule of a biological pore. These findings demonstrate the utility of MOSAIC and the ADEPT algorithm, and offer a new tool that can improve the analysis of nanopore-based measurements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.