Evidence map›Paper›PMID 27797450›Full record

ArticleJournal of thrombosis and haemostasis : JTH2016

S2'-subsite variations between human and mouse enzymes (plasmin, factor XIa, kallikrein) elucidate inhibition differences by tissue factor pathway inhibitor -2 domain1-wild-type, Leu17Arg-mutant and aprotinin.

K Vadivel, Y Kumar, G I Ogueli, S M Ponnuraj, P Wongkongkathep, J A Loo, M S Bajaj, S P Bajaj

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

K VadivelDepartment of Orthopaedic Surgery, University of California, Los Angeles, CA, USA.
Y KumarDepartment of Orthopaedic Surgery, University of California, Los Angeles, CA, USA.
G I OgueliDepartment of Orthopaedic Surgery, University of California, Los Angeles, CA, USA.
S M PonnurajDepartment of Orthopaedic Surgery, University of California, Los Angeles, CA, USA.
P WongkongkathepDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA.
J A LooDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA.
M S BajajDivision of Pulmonology and Critical Care, Department of Medicine, University of California, Los Angeles, CA, USA.
S P BajajDepartment of Orthopaedic Surgery, University of California, Los Angeles, CA, USA.
University of California, Los Angeles · US

Funding

UV Laser for Photodissociation-Mass Spectrometry of Proteins and Protein ComplexesR01GM103479 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LOO, JOSEPH A · 2012 to 2021
$3.2M
Structural Biology of Tissue Factor-Induced Coagulation: Therapeutic ImplicationsR21HL122878 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BAJAJ, S PAUL · 2014 to 2015
$421k
NHLBI NIH HHS R21 HL122878NIGMS NIH HHS R01 GM103479
6 · The paper itself

Abstract

Essentials Current antifibrinolytics - aminocaproic acid and tranexamic acid-can cause seizures or renal injury. KD1 SUMMARY: Background Using tissue factor pathway inhibitor (TFPI)-2 Kunitz domain1 (KD1), we obtained a bifunctional antifibrinolytic molecule (KD1

Indexed as

AnimalsAntifibrinolytic AgentsAprotininCattleFactor XIaFibrin Fibrinogen Degradation ProductsFibrinolysinFibrinolysisGlycoproteinsHemorrhageHumansKallikreinsLeucineLiverMiceModels, MolecularAntifibrinolytic AgentsAprotininFactor XIaFibrin Fibrinogen Degradation Productsfibrin fragment DFibrinolysinGlycoproteinsKallikreinsLeucinePeptide Hydrolasestissue-factor-pathway inhibitor 2Tranexamic AcidTrypsinantifibrinolytic agentsaprotininfibrinolysisTFPI-2tranexamic acid

Identifiers

PMID27797450
PMCPMC5504414
OpenAlexW2552708678

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.