ArticleBrain imaging and behavior2017
White matter microstructure of patients with neurofibromatosis type 1 and its relation to inhibitory control.
Article in Brain imaging and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Social Communication in Ras Pathway Disorders: A Comprehensive Review From Genetics to Behavior in Neurofibromatosis Type 1 and Noonan Syndrome.Biological psychiatry · 2025Pooled it
- A systematic review and meta-analysis of intellectual, neuropsychological, and psychoeducational functioning in neurofibromatosis type 1.American journal of medical genetics. Part A · 2022Pooled it
- Genetic activation of ERK2 recapitulates core neurodevelopmental features of Rasopathy syndromes in mice.HGG advances · 2026Article
- Article
- A Multi-parametric MRI and Machine Learning Study of Cerebellar Structure in Youth with Neurofibromatosis Type 1.Cerebellum (London, England) · 2026Article
- Review
- Genetic activation of ERK2 recapitulates core neurodevelopmental features of Rasopathy syndromes in mice.bioRxiv : the preprint server for biology · 2025Article
- White Matter Correlates of Psychopathic Traits in a Japanese Community Sample: Sex Matters!The European journal of neuroscience · 2025Article
- Associations Between Preterm Birth, Inhibitory Control-Implicated Brain Regions and Tracts, and Inhibitory Control Task Performance in Children: Consideration of Socioeconomic Context.Child psychiatry and human development · 2025Article
- Age-related white matter alterations in children with neurofibromatosis type 1: a diffusion MRI tractography study.Frontiers in neuroscience · 2025Article
- The Lack of Ad Hoc Neuropsychological Assessment in Adults with Neurofibromatosis: A Systematic Review.Journal of clinical medicine · 2024Review
- Impact of pathogenic variants of the Ras-mitogen-activated protein kinase pathway on major white matter tracts in the human brain.Brain communications · 2024Article
- Review
- Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1.Journal of autism and developmental disorders · 2022Article
- Auditory Dysfunction Among Individuals With Neurofibromatosis Type 1.JAMA network open · 2021Article
- Non-Oncological Neuroradiological Manifestations in NF1 and Their Clinical Implications.Cancers · 2021Review
- An executive functioning perspective in neurofibromatosis type 1: from ADHD and autism spectrum disorder to research domains.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Review
- Brain-wide structural and functional disruption in mice with oligodendrocyte-specificProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Effect of age and neurofibromatosis type 1 status on white matter integrity in the optic radiations.Neuro-oncology advances · 2020Article
- Neurofibromatosis Type 1: Ocular Electrophysiological and Perimetric Anomalies.Eye and brain · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
Neurofibromatosis Type 1 (NF1) is commonly associated with deficits in executive functions such as working memory and inhibitory control. A valid biomarker to describe the pathological basis of these deficits in NF1 is not available. The aim of this study was to investigate whether any abnormalities in white matter integrity of the executive function related anterior thalamic radiation (ATR), cingulate bundle (CB), and superior longitudinal fasciculus (SLF) may be regarded as a pathological basis for inhibitory control deficits in adolescents with NF1. Sixteen NF1 patients and 32 healthy controls underwent 3 T DTI MRI scanning. Whole brain-, ATR-, CB-, and SLF-white matter integrity were studied using fractional anisotropy, mean (MD), radial, and axial (DA) diffusivity. Correlation analyses between white matter metrics and inhibitory control (as measured with a computerized task) were performed. Also, verbal and performance abilities (IQ-estimates) were assessed and correlated with white matter metrics. Patients showed significant whole brain- and local microstructural pathology when compared to healthy controls in all measures. In NF1-patients, whole-brain (MD: r = .646 and DA: r = .673) and ATR- (r-range: -.405-.771), but not the CB- (r-range: -.307-.472) and SLF- (r-range: -.187-.406) white matter integrity, were correlated with inhibitory control. Verbal and performance abilities were not associated with white matter pathology. In NF1, white matter abnormalities are observed throughout the brain, but damage to the ATR seems specifically, or at least most strongly related to inhibitory control. Future studies should examine whether reduced white matter integrity in other brain regions or tracts is (more strongly) associated with different aspects of the cognitive-behavioral phenotype associated with NF1.
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