ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2017
Unjoined primary and secondary neural tubes: junctional neural tube defect, a new form of spinal dysraphism caused by disturbance of junctional neurulation.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed.
- Microsurgical Untethering of Pediatric Lipomyelomeningocele: A Stepwise, Photo-Illustrated Technical Note.Brain sciences · 2026Article
- Quantitative live imaging reveals PRICKLE1 controls junctional neural tube morphogenesis independent of Planar Cell Polarity.Nature communications · 2026Article
- Junctional Neural Tube Defect : Two Case Report.Journal of Korean Neurosurgical Society · 2025Article
- Differences between Myeloschisis and Myelomeningocele in Patients Undergoing Prenatal Repair of Open Spina Bifida.Fetal diagnosis and therapy · 2025Article
- Article
- Surgery for spina bifida occulta: spinal lipoma and tethered spinal cord.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Junctional Neural Tube Defect (JNTD): A Rare and Relatively New Spinal Dysraphic Malformation.Advances and technical standards in neurosurgery · 2023Article
- A New Surgical Paradigm for Postnatal Repair of Open Neural Tube Defects Using Intraoperative Neurophysiology Monitoring.Advances and technical standards in neurosurgery · 2023Article
- Severe type of segmental spinal dysgenesis with complete disconnection of the spinal cord and vertebra associated with open neural tube defect.Surgical neurology international · 2023Article
- Focal Spinal Nondisjunctional Disorders: Including a Discussion on the Embryogenesis of Cranial Focal Nondisjunctional Lesions.Advances and technical standards in neurosurgery · 2023Review
- Disorders of Secondary Neurulation: Suggestion of a New Classification According to Pathoembryogenesis.Advances and technical standards in neurosurgery · 2022Article
- Disorders of Secondary Neurulation : Mainly Focused on Pathoembryogenesis.Journal of Korean Neurosurgical Society · 2021Article
- Junctional Neurulation : A Junction between Primary and Secondary Neural Tubes.Journal of Korean Neurosurgical Society · 2021Article
- New surgical paradigm for open neural tube defects.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Do junctional neural tube defect and segmental spinal dysgenesis have the same pathoembryological background?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Spinal Dysraphism in the Last Two Decades : What I Have Seen during the Era of Dynamic Advancement.Journal of Korean Neurosurgical Society · 2020Article
- Perspectives on Spinal Dysraphism : Past, Present, and Future.Journal of Korean Neurosurgical Society · 2020Article
- Junctional Neural Tube Defect.Journal of Korean Neurosurgical Society · 2020Article
- Do junctional neural tube defect and segmental spinal dysgenesis have the same pathoembryological background?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Surgical histopathology of limited dorsal myeloschisis with flat skin lesion.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
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Abstract
introductionPrimary and secondary neurulation are the two known processes that form the central neuraxis of vertebrates. Human phenotypes of neural tube defects (NTDs) mostly fall into two corresponding categories consistent with the two types of developmental sequence: primary NTD features an open skin defect, an exposed, unclosed neural plate (hence an open neural tube defect, or ONTD), and an unformed or poorly formed secondary neural tube, and secondary NTD with no skin abnormality (hence a closed NTD) and a malformed conus caudal to a well-developed primary neural tube. METHODS AND
resultsWe encountered three cases of a previously unrecorded form of spinal dysraphism in which the primary and secondary neural tubes are individually formed but are physically separated far apart and functionally disconnected from each other. One patient was operated on, in whom both the lumbosacral spinal cord from primary neurulation and the conus from secondary neurulation are each anatomically complete and endowed with functioning segmental motor roots tested by intraoperative triggered electromyography and direct spinal cord stimulation. The remarkable feature is that the two neural tubes are unjoined except by a functionally inert, probably non-neural band.
conclusionThe developmental error of this peculiar malformation probably occurs during the critical transition between the end of primary and the beginning of secondary neurulation, in a stage aptly called junctional neurulation. We describe the current knowledge concerning junctional neurulation and speculate on the embryogenesis of this new class of spinal dysraphism, which we call junctional neural tube defect.
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