Evidence map›Paper›PMID 27796514›Full record

ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2017

Results of a nation-wide retrospective study of lymphadenectomy for esophagogastric junction carcinoma.

Hiroharu Yamashita, Yasuyuki Seto, Takeshi Sano, Hiroyasu Makuuchi, Nobutoshi Ando, Mitsuru Sasako, Japanese Gastric Cancer Association and the Japan Esophageal Society

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04710758 (Prospective Randomized Controlled Multicenter Clinical Trial For Comparison Of Long-term Outcomes Between Laparoscopic And Open Total Gastrectomy In Patients With Locally Advanced Gastric Cancer), which is not on this map. Cited by 133 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04710758 narecruitingnot on this mapstarted 2021, after this paper: background citation

Prospective Randomized Controlled Multicenter Clinical Trial For Comparison Of Long-term Outcomes Between Laparoscopic And Open Total Gastrectomy In Patients With Locally Advanced Gastric Cancer

TypeinterventionalSponsorShanghai Zhongshan HospitalRan2021 to 2028Enrolled1,018ConditionsStomach NeoplasmsArmsLaparoscopic total gastrectomy, Open total gastrectomy
3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Clinical practice guidelines for esophagogastric junction cancer: Upper GI Oncology Summit 2023.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024
    Guideline
  2. Pooled it
  3. Proximal Gastrectomy Versus Total Gastrectomy for Siewert II/III Adenocarcinoma of the Gastroesophageal Junction: a Systematic Review and Meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022
    Pooled it
  4. Pooled it
  5. Pooled it
  6. [Updated German S3 guidelines on esophageal cancer and supplements from a surgical perspective].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2019
    Guideline
  7. Guideline
  8. Trial
  9. Trial
  10. Phase II study of S-1 and oxaliplatin as neoadjuvant chemotherapy for locally advanced adenocarcinoma of the gastric or esophagogastric junction: KSCC1601.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2022
    Trial
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Estimation of esophageal involvement length in esophagogastric junction tumors using PET-CT.Esophagus : official journal of the Japan Esophageal Society · 2026
    Article
  18. Review
  19. Article
  20. Article

73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hiroharu YamashitaDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. hyamashi-tky@umin.net.ORCID http://orcid.org/0000-0002-9468-3716
Yasuyuki SetoDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Takeshi SanoDepartment of Gastroenterological Surgery, Cancer Institute Hospital, 3-8-31, Ariake, Koto-ku, Tokyo, 135-8550, Japan.
Hiroyasu MakuuchiDepartment of Surgery, Tokai University School of Medicine, Isehara, Kanagawa, 259-1193, Japan.
Nobutoshi AndoInternational Goodwill Hospital, Yokohama, Kanagawa, 245-0006, Japan.
Mitsuru SasakoDepartment of Multidisciplinary Surgical Oncology, Hyogo College of Medicine, 1-1, Mukogawacho, Nishinomiya, Hyogo, 663-8501, Japan.
Japanese Gastric Cancer Association and the Japan Esophageal Society

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEsophagogastric junction (EGJ) carcinoma has attracted considerable attention because of the marked increase in its incidence globally. However, the optimal extent of esophagogastric resection for this tumor entity remains highly controversial.

methodsThis was a questionnaire-based national retrospective study undertaken in an attempt to define the optimal extent of lymph node dissection for EGJ cancer. Data from patients with EGJ carcinoma, less than 40 mm in diameter, who underwent R0 resection between January 2001 and December 2010 were reviewed.

resultsClinical records of 2807 patients without preoperative therapy were included in the analysis. There are distinct disparities in terms of the nodal dissection rate according to histology and the predominant tumor location. Nodal metastases frequently involved the abdominal nodes, especially those at the right and left cardia, lesser curvature and along the left gastric artery. Nodes along the distal portion of the stomach were much less often metastatic, and their dissection seemed unlikely to be beneficial. Lower mediastinal node dissection might contribute to improving survival for patients with esophagus-predominant EGJ cancer. However, due to low dissection rates for nodes of the middle and upper mediastinum, no conclusive result was obtained regarding the optimal extent of nodal dissection in this region.

conclusionsComplete nodal clearance along the distal portion of the stomach offers marginal survival benefits for patients with EGJ cancers less than 4 cm in diameter. The optimal extent of esophageal resection and the benefits of mediastinal node dissection remain issues to be addressed in managing patients with esophagus-predominant EGJ cancers.

Indexed as

Lymph Node ExcisionAdenocarcinomaAdolescentAdultAgedAged, 80 and overCarcinoma, Squamous CellEsophagogastric JunctionFemaleFollow-Up StudiesGastrectomyHumansLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessAdenocarcinomaEsophagogastric junctionProximal gastrectomySquamous cell carcinoma

Identifiers

PMID27796514

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.