ArticleEuropean journal of clinical pharmacology2017
Use of pharmacy dispensing data to measure adherence and identify nonadherence with oral hypoglycemic agents.
Article in European journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- A narrative review of antiseizure medication adherence in epilepsy: determinants to clinical implications.Encephalitis (Seoul, Korea) · 2026Article
- Assessing Therapeutic Choices and Adherence to Antidiabetic Therapy in Naïve Patients: A Retrospective Observational Study in a Local Health Authority of the Piedmont Region (Italy).Healthcare (Basel, Switzerland) · 2023Article
- Genotyping for HLA Risk Alleles to Prevent Drug Hypersensitivity Reactions: Impact Analysis.Pharmaceuticals (Basel, Switzerland) · 2021Article
- An estimation of patients at potential risk for drug-induced sexual dysfunction using pharmacy dispensing data.Family practice · 2021Article
- Benzodiazepine and unhealthy alcohol use among adult outpatients.The American journal of managed care · 2019Article
- Closing the Gap: Identifying Rates and Reasons for Nonadherence in a Specialty Population.Journal of managed care & specialty pharmacy · 2019Article
- Anticholinergic and sedative medication use in older community-dwelling people: A national population study in the Netherlands.Pharmacoepidemiology and drug safety · 2019Article
- Using Dispensing Data to Evaluate Adherence Implementation Rates in Community Pharmacy.Frontiers in pharmacology · 2019Article
- Considerations of prescribers and pharmacists for the use of non-selective β-blockers in asthma and COPD patients: An explorative study.Journal of evaluation in clinical practice · 2018Observational
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeA framework for calculation of adherence for oral hypoglycemic agents (OHAs) based on data from health-insurance claims is available. Pharmacy dispensing data aid identification of nonadherent patients in pharmacy practices. However, use of these data for calculation of OHA adherence requires additional methodological categories. We examined the impact of different methodological choices on estimation of OHA adherence using pharmacy dispensing data.
methodsFour methodological categories were added to the framework available to be used for adherence calculation with pharmacy dispensing data. Three adherence measures were defined to supply pharmacists with significant information on OHA use of their patients: (i) percentage of days covered by use periods of dispensed medication (PDC), (ii) mean rate of adherent patients with a PDC ≥80 % (MRAP80), and (iii) mean number of nonadherent patients (MNNP80) per pharmacy with a PDC <80 %. A basic scenario was developed from 16 methodological categories. Consequences of choices for different parameters within these categories on the scores of the three adherence measures were calculated from dispensing data between July 2013 and July 2014.
resultsData were available for 604,500 OHA users in 1737 community pharmacies in the Netherlands. For the basic scenario, mean PDC for OHA was 88.3 %. MRAP80 was 80.3 %, which corresponded to an average of 69 nonadherent patients per pharmacy. Different choices for parameter values resulted in score variations for PDC of 85.0-91.8 %, for MRAP80 of 75.3-86.1 %, and between 49 and 92 MNNP80 per pharmacy.
conclusionSixteen methodological categories specified calculation of OHA adherence based on pharmacy dispensing data. Adherence scores expressed as percentages were relatively robust to variation in parameter values, but differed substantially for the absolute numbers of nonadherent patients per pharmacy.
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