ArticleScientific reports2016
The osteogenic potential of human bone callus.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Effect of perioperative multistrain probiotics on the CT callus volume fraction at 12 weeks after surgery for closed tibial shaft fracture: a single-center randomized controlled study.Frontiers in cellular and infection microbiology · 2026Trial
- Osteogenic Potential of Bone Callus: A Cross-sectional Study on Microscopic Structure and Healing Stages.Journal of orthopaedic case reports · 2026Article
- A spatiotemporal atlas of senescence-associated secretory phenotype in fracture healing: stage-dependent mechanisms and therapeutic windows.Inflammation and regeneration · 2026Review
- Long-term tissue engineered periosteum-mediated allograft healing is hindered due to persistent fibrosis and limited allograft remodeling.Bone reports · 2025Article
- Degradable poly-lactic-co-glycolic acid and non-degradable polymer implants result in similar fracture healing at early timepoints.Clinical biomechanics (Bristol, Avon) · 2025Article
- Use of bone callus as a source of bone graft for concurrent tibial malunion repair and contralateral pantarsal arthrodesis in a domestic shorthair cat-a case report.Frontiers in veterinary science · 2025Article
- The influence of partial union on the mechanical strength of scaphoid fractures: a finite element study.The Journal of hand surgery, European volume · 2023Article
- Sex differences in systemic bone and muscle loss following femur fracture in mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- TAZ inhibits osteoclastogenesis by attenuating TAK1/NF-κB signaling.Bone research · 2021Article
- Protein profiling of osteosarcoma tissue and soft callus unveils activation of the unfolded protein response pathway.International journal of oncology · 2019Article
- Tendon healing in the context of complex fractures.Clinical reviews in bone and mineral metabolism · 2018Article
- Small Molecules Enhance Scaffold-Based Bone Grafts via Purinergic Receptor Signaling in Stem Cells.International journal of molecular sciences · 2018Review
- Targeting skeletal endothelium to ameliorate bone loss.Nature medicine · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone callus, generated during fracture healing, is commonly discarded during surgical procedures. The aim of this study was to investigate the osteogenic potential of bone callus and its possible use as autograft material for patients needing bone grafts. Histology, immunohistochemistry, micro-computed tomography, and biomechanics were performed to examine osteogenic cells, osteoinductive factors, and the osteoconductive structure of bone callus. Alkaline phosphatase-positive osteoblasts, osteoinductive factors (including BMP2, FGF2, TGFB1, and IGF1), and a porous structure were found in bone callus. Early-stage callus (within 3 months after fracture) presented significantly improved osteogenic properties compared to medium- (3-9 months) and late-stage (longer than 9 months) callus. The results revealed that bone callus induced new bone formation in a nude mouse model. Early-stage callus showed better performance to medium- and late-stage callus in the induction of new bone formation at both 8 and 12 weeks. These findings indicated that bone callus, especially early-stage callus, possesses osteogenic potential and can potentially serve as an alternative source of material for bone grafts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.