Evidence map›Paper›PMID 27796328›Full record

ArticleScientific reports2016

Clinical analysis of HIV/AIDS patients with drug eruption in Yunnan, China.

Yu-Ye Li, Yong-Mei Jin, Li-Ping He, Jin-Song Bai, Jun Liu, Min Yu, Jian-Hua Chen, Jing Wen, Yi-Qun Kuang

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yu-Ye LiDepartment of Dermatology and Venerology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, P. R. China.
Yong-Mei JinDepartment of Dermatology and Venerology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, P. R. China.
Li-Ping HeSchool of Public Health, Kunming Medical University, Kunming 650500, P. R. China.
Jin-Song BaiDepartment of HIV/AIDS, The Third People's Hospital of Kunming, Kunming 650041, P. R. China.
Jun LiuDepartment of HIV/AIDS, The Third People's Hospital of Kunming, Kunming 650041, P. R. China.
Min YuDepartment of HIV/AIDS, The Third People's Hospital of Kunming, Kunming 650041, P. R. China.
Jian-Hua ChenDepartment of HIV/AIDS, The Third People's Hospital of Kunming, Kunming 650041, P. R. China.
Jing WenCenter for Translational Medicine, Huaihe Clinical College, Henan University, Kaifeng 475000, P. R. China.
Yi-Qun KuangCenter for Translational Medicine, Huaihe Clinical College, Henan University, Kaifeng 475000, P. R. China.
Kunming Third People's Hospital · CNHenan University Huaihe Hospital and Huaihe Clinical Institute · CNKunming Medical University · CNFirst Affiliated Hospital of Kunming Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug eruption is the most common clinical presentation in patients with HIV/AIDS. The systemic clinical and risk factors associated with drug eruption remain unknown. A retrospective analysis in HIV/AIDS patients with drug eruption was carried out with demographic data, epidemiological data, clinical characteristics, laboratory data and follow-up data. The risk factors correlated with prognosis were assessed by case control analysis. A total of 134 out of 1817 HIV/AIDS patients (7.4%) presented drug eruptions. The major class of sensitizing drug was HAART drugs (47.7%), followed by antibiotics (47.0%). Nevirapine (39.6%) was the most common sensitizing drug in the HAART regimens. The patients received HAART or had allergic history were prone to develop drug eruption. The alanine aminotransferase, albumin, globulin, creatinine, blood urea nitrogen (BUN), lymphocytes, red blood cells (RBC) and eosinophils of the drug eruption patients were significantly different the control patients. The allergic history, opportunistic infection, viral load, CD4 cell count, high globulin and low albumin were the risk factors correlated with death in HIV/AIDS patients with drug eruption. It is proposed that patients with higher viral loads, higher globulin levels and lower white blood cells (WBC) should be given special attention for the prevention of complications and death.

Indexed as

Acquired Immunodeficiency SyndromeAdultAgedAged, 80 and overAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountChinaDrug EruptionsFemaleHIV InfectionsHumansMaleMiddle AgedNevirapineRetrospective StudiesSerum GlobulinsNevirapineSerum Globulins

Identifiers

PMID27796328
PMCPMC5086857
OpenAlexW2546316031

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.