ArticleScientific reports2016
Ductular reaction-on-a-chip: Microfluidic co-cultures to study stem cell fate selection during liver injury.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Cholangiocyte biology in primary sclerosing cholangitis and other cholangiopathies: pathogenesis, clinical insights, and experimental tools.Physiological reviews · 2026Review
- Article
- Prospect ofFrontiers in toxicology · 2021Review
- Microfluidic confinement enhances phenotype and function of hepatocyte spheroids.American journal of physiology. Cell physiology · 2020Article
- Engineered Liver-on-a-Chip Platform to Mimic Liver Functions and Its Biomedical Applications: A Review.Micromachines · 2019Review
- A cell lines derived microfluidic liver model for investigation of hepatotoxicity induced by drug-drug interaction.Biomicrofluidics · 2019Article
- Effects of Co-Culture Media on Hepatic Differentiation of hiPSC with or without HUVEC Co-Culture.International journal of molecular sciences · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Liver injury modulates local microenvironment, triggering production of signals that instruct stem cell fate choices. In this study, we employed a microfluidic co-culture system to recreate important interactions in the liver stem cell niche, those between adult hepatocytes and liver progenitor cells (LPCs). We demonstrate that pluripotent stem cell-derived LPCs choose hepatic fate when cultured next to healthy hepatocytes but begin biliary differentiation program when co-cultured with injured hepatocytes. We connect this fate selection to skewing in production of hepatocyte growth factor (HGF) and transforming growth factor (TGF)-β1 caused by injury. Significantly, biliary fate selection of LPCs was not observed in the absence of hepatocytes nor did it happen in the presence of TGF-β inhibitors. Our study demonstrates that microfluidic culture systems may offer an interesting new tool for dissecting cellular interactions leading to aberrant stem cell differentiation during injury.
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Registered trials
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