ArticleScientific reports2016
Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 7 citations in OpenAlex.
- UBE2N deficiency contributes to MASH development via p62-regulated mitophagy and PANoptosis.Nature metabolism · 2026Article
- Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies.Signal transduction and targeted therapy · 2023Review
- K63 ubiquitination in immune signaling.Trends in immunology · 2022Review
- Key genes and co-expression network analysis in the livers of type 2 diabetes patients.Journal of diabetes investigation · 2019Article
- Chronic exercise reduces hypothalamic transforming growth factor-β1 in middle-aged obese mice.Aging · 2017Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
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Abstract
Obesity is associated with low-grade inflammation that leads to insulin resistance and type 2 diabetes via Toll-like Receptor (TLR) and TNF-family cytokine receptor (TNFR) signaling pathways. Ubc13 is an ubiquitin-conjugating enzyme responsible for non-canonical K63-linked polyubiquitination of TNF receptor-associated factor (TRAF)-family adapter proteins involved in TLR and TNFR pathways. However, the relationship between Ubc13 and metabolic disease remains unclear. In this study, we investigated the role of Ubc13 in insulin resistance and high-fat diet (HFD)-induced obesity. We compared wild-type (WT) and Ubc13 haploinsufficient (ubc13
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