ArticleCellular & molecular immunology2017
Respective IL-17A production by γδ T and Th17 cells and its implication in host defense against chlamydial lung infection.
Article in Cellular & molecular immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 36 citations in OpenAlex.
- HDAC6 Promotes Host Defense Against Chlamydial Lung Infections by Regulating M2-Th2 Responses.International journal of molecular sciences · 2026Article
- CCR2 signaling regulates anti-chlamydia T cell immune responses in the airway.PLoS pathogens · 2025Article
- The Emerging Roles and Therapeutic Potential of Unconventional T Cells in Sepsis.Journal of inflammation research · 2025Review
- Inflammatory and Immunomodulatory Effects of Tripterygium wilfordii Multiglycoside in Mouse Models of Psoriasis Keratinocytes.Chinese journal of integrative medicine · 2024Article
- Insights into innate immune cell evasion byFrontiers in immunology · 2024Review
- Article
- Th17/Treg Imbalance: Implications in Lung Inflammatory Diseases.International journal of molecular sciences · 2023Review
- Protein Phosphatase 2A: Role in T Cells and Diseases.Journal of immunology research · 2023Review
- The Role of IL-17 During Infections in the Female Reproductive Tract.Frontiers in immunology · 2022Review
- T-helper 22 cells develop as a distinct lineage from Th17 cells during bacterial infection and phenotypic stability is regulated by T-bet.Mucosal immunology · 2021Article
- SND1 promotes Th1/17 immunity against chlamydial lung infection through enhancing dendritic cell function.PLoS pathogens · 2021Article
- miR-126-5p regulates H9c2 cell proliferation and apoptosis under hypoxic conditions by targeting IL-17A.Experimental and therapeutic medicine · 2021Article
- Insights Into Host Cell Cytokines inFrontiers in immunology · 2021Review
- IL-17A-producing T cells exacerbate fine particulate matter-induced lung inflammation and fibrosis by inhibiting PI3K/Akt/mTOR-mediated autophagy.Journal of cellular and molecular medicine · 2020Article
- Intrinsically altered lung-resident γδT cells control lung melanoma by producing interleukin-17A in the elderly.Aging cell · 2020Article
- Anti-inflammatory activity of diindolylmethane alleviates Riemerella anatipestifer infection in ducks.PloS one · 2020Article
- Passive smoking induces pediatric asthma by affecting the balance of Treg/Th17 cells.Pediatric research · 2019Article
- Tissue-resident lymphocytes: from adaptive to innate immunity.Cellular & molecular immunology · 2019Review
- Phosphatase PP2A is essential for TProceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Roles of Liver-Resident Lymphocytes in Liver Diseases.Frontiers in immunology · 2019Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of IL-17A is important in protection against lung infection with Chlamydiae, an obligate intracellular bacterial pathogen. In this study, we explored the producers of IL-17A in chlamydial lung infection and specifically tested the role of major IL-17A producers in protective immunity. We found that γδT cells and Th17 cells are the major producers of IL-17A at the early and later stages of chlamydial infection, respectively. Depletion of γδT cells in vivo at the early postinfection (p.i.) stage, when most γδT cells produce IL-17A, failed to alter Th1 responses and bacterial clearance. In contrast, the blockade of IL-17A at the time when IL-17A was mainly produced by Th17 (day 7 p.i.) markedly reduced the Th1 response and increased chlamydial growth. The data suggest that the γδ T cell is the highest producer of IL-17A in the very early stages of infection, but the protection conferred by IL-17A is mainly mediated by Th17 cells. In addition, we found that depletion of γδ T cells reduced IL-1α production by dendritic cells, which was associated with a reduced Th17 response. This finding is helpful to understand the variable role of IL-17A in different infections and to develop preventive and therapeutic approaches against infectious diseases by targeting IL-17A.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.