Evidence map›Paper›PMID 27796131›Full record

Trial reportAIDS research and human retroviruses2017

Maternal Highly Active Antiretroviral Therapy Reduces Vertical Cytomegalovirus Transmission But Does Not Reduce Breast Milk Cytomegalovirus Levels.

Jennifer A Slyker, Barbra Richardson, Michael H Chung, Claire Atkinson, Kristjana H Ásbjörnsdóttir, Dara A Lehman, Michael Boeckh, Vincent Emery, James Kiarie, Grace John-Stewart

Registry-linked trialOpen access · greenAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS research and human retroviruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00167674 (ARVs to Prevent Breastmilk HIV), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00167674 phase2completednot on this map

ARVs to Prevent Breastmilk HIV:Viral and Immune Responses

TypeinterventionalSponsorUniversity of WashingtonRan2003 to 2006Enrolled58ConditionsHIV InfectionsArmsCombined short-course zidovudine/nevirapine, HAART
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Jennifer A Slyker1 Department of Global Health, University of Washington , Seattle, Washington.
Barbra Richardson2 Department of Biostatistics, University of Washington , Seattle, Washington.
Michael H Chung1 Department of Global Health, University of Washington , Seattle, Washington.
Claire Atkinson6 Institute for Immunity and Transplantation, University College , London, London, United Kingdom .
Kristjana H Ásbjörnsdóttir5 Department of Epidemiology, University of Washington , Seattle, Washington.
Dara A Lehman1 Department of Global Health, University of Washington , Seattle, Washington.
Michael Boeckh4 Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington , Seattle, Washington.
Vincent Emery9 Department of Microbial and Cellular Sciences, University of Surrey , Guildford, United Kingdom .
James Kiarie10 Department of Obstetrics and Gynaecology, School of Medicine, University of Nairobi , Nairobi, Kenya .
Grace John-Stewart1 Department of Global Health, University of Washington , Seattle, Washington.
University of Washington · USFred Hutch Cancer Center · USUniversity of Nairobi · KEUniversity of Surrey · GB

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
Urgent Versus Post-Stabilization ART in HIV+ Children with Severe Co-infectionsR01HD023412 · NICHD · UNIVERSITY OF WASHINGTON · PI Grace C. John-Stewart, DALTON CHEKOKO WAMALWA · 1987 to 2026
$12.2M
Pediatric HIV-1 in Africa: Pathogenesis and ManagementK24HD054314 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2006 to 2016
$1.2M
HAART Adherence Interventions in Africa: an RCTK23AI065222 · NIAID · UNIVERSITY OF WASHINGTON · PI CHUNG, MICHAEL HOONBAE · 2005 to 2009
$639k
Vertical CMV transmission in the setting of maternal HIV-1 infection in KenyaK01AI087369 · NIAID · UNIVERSITY OF WASHINGTON · PI SLYKER, JENNIFER ANN · 2010 to 2014
$616k
NIAID NIH HHS K01 AI087369NIAID NIH HHS K23 AI065222NIAID NIH HHS P30 AI027757NIAID NIH HHS T32 AI007140NICHD NIH HHS K24 HD054314NICHD NIH HHS R01 HD023412
6 · The paper itself

Abstract

To evaluate the impact of highly active antiretroviral therapy (HAART) on CMV transmission and breast milk level in the context of maternal HIV. Specimens from a randomized trial conducted in Nairobi, Kenya between 2003-2005 were used to compare CMV transmission and breast milk levels between mother-infant pairs randomized to HAART versus short-course antenatal zidovudine plus single-dose nevirapine (ZDV/sdNVP) for prevention of mother-to-child HIV transmission (PMTCT). Fifty-one antiretroviral-naïve women ≤32 weeks gestation, and CD4 between 200-500 cells/mm CLINICAL TRIALS REGISTRATION: NCT00167674.

Indexed as

Antiretroviral Therapy, Highly ActiveViral LoadAdultCytomegalovirusCytomegalovirus InfectionsFemaleHIV InfectionsHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalKenyaMilk, HumanPregnancyPregnancy Complications, InfectiousYoung Adultantiretroviral therapybreast milkcytomegalovirusHAARThuman immunodeficiency virusneonates

Identifiers

PMID27796131
PMCPMC5372773
OpenAlexW2563922582

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.