Evidence map›Paper›PMID 27796082›Full record

ArticleJournal of magnetic resonance imaging : JMRI2017

PET/MRI of metabolic activity in osteoarthritis: A feasibility study.

Feliks Kogan, Audrey P Fan, Emily J McWalter, Edwin H G Oei, Andrew Quon, Garry E Gold

Registry-linked trialAbstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07494838 (IMAGES), which is not on this map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07494838 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success

TypeinterventionalSponsorLucas R. Cusumano, MDRan2026 to 2027Enrolled25ConditionsKnee Osteoarthritis, Knee Discomfort, Knee Pain Chronic, Knee Swelling PainArmsEmbolization
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
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  6. [EJNMMI research · 2025
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  16. Article
  17. Imaging of knee osteoarthritis: a review of multimodal diagnostic approach.Quantitative imaging in medicine and surgery · 2023
    Review
  18. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Feliks KoganDepartment of Radiology, Stanford University, Stanford, California, USA.
Audrey P FanDepartment of Radiology, Stanford University, Stanford, California, USA.
Emily J McWalterDepartment of Mechanical Engineering, University of Saskatchewan, Saskatoon, Canada.
Edwin H G OeiDepartment of Radiology & Nuclear Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
Andrew QuonDepartment of Radiology, Stanford University, Stanford, California, USA.
Garry E GoldDepartment of Radiology, Stanford University, Stanford, California, USA.
Stanford University · USErasmus MC · NLUniversity of Saskatchewan · CA

Funding

Rapid MRI for Evaluation of OsteoarthritisR01EB002524 · NIBIB · STANFORD UNIVERSITY · PI Akshay Chaudhari, Garry E Gold · 2003 to 2026
$10.1M
Advanced MR Imaging of Early OsteoarthritisK24AR062068 · NIAMS · STANFORD UNIVERSITY · PI GOLD, GARRY E · 2012 to 2022
$1.7M
NIAMS NIH HHS K24 AR062068NIBIB NIH HHS R01 EB002524
6 · The paper itself

Abstract

purposeTo evaluate positron emission tomography / magnetic resonance imaging (PET/MRI) knee imaging to detect and characterize osseous metabolic abnormalities and correlate PET radiotracer uptake with osseous abnormalities and cartilage degeneration observed on MRI. MATERIALS AND

methodsBoth knees of 22 subjects with knee pain or injury were scanned at one timepoint, without gadolinium, on a hybrid 3.0T PET-MRI system following injection of

resultsSUV

conclusionPET/MRI can simultaneously assess multiple early metabolic and morphologic markers of knee OA across multiple tissues in the joint. Our findings suggest that PET/MR may detect metabolic abnormalities in subchondral bone, which appear normal on MRI. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 1 J. MAGN. RESON. IMAGING 2017;45:1736-1745.

Indexed as

AdultBiomarkersBone Diseases, MetabolicContrast MediaFemaleFluorodeoxyglucose F18HumansImage EnhancementImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMultimodal ImagingOsteoarthritis, KneePositron-Emission TomographyRadiopharmaceuticalsReproducibility of ResultsBiomarkersContrast MediaFluorodeoxyglucose F18Radiopharmaceuticalsbone remodelingosteoarthritisPET/MRI

Identifiers

PMID27796082
PMCPMC5761655
OpenAlexW2546830251

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.