Evidence map›Paper›PMID 27796063›Full record

ArticleGlia2017

Endogenous GABA controls oligodendrocyte lineage cell number, myelination, and CNS internode length.

Nicola B Hamilton, Laura E Clarke, I Lorena Arancibia-Carcamo, Eleni Kougioumtzidou, Moritz Matthey, Ragnhildur Káradóttir, Louise Whiteley, Linda H Bergersen, William D Richardson, David Attwell

Open access · hybridAbstract read
In one paragraph

Article in Glia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 104 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Central Dysmyelination in SSADH-Deficient Humans and Mice.Annals of clinical and translational neurology · 2025
    Observational
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. GABA and glutamate measurements in temporal cortex of autistic children.Autism research : official journal of the International Society for Autism Research · 2024
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Exploring CaeNeuro · 2024
    Article
  17. Review
  18. Review
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Nicola B HamiltonDepartment of Neuroscience, Pharmacology and Physiology, University College London, London, WC1E 6BT, United Kingdom.
Laura E ClarkeDepartment of Neuroscience, Pharmacology and Physiology, University College London, London, WC1E 6BT, United Kingdom.
I Lorena Arancibia-CarcamoDepartment of Neuroscience, Pharmacology and Physiology, University College London, London, WC1E 6BT, United Kingdom.
Eleni KougioumtzidouDepartment of Cell and Developmental Biology, Wolfson Institute for Biomedical Research, University College London, London, WC1E 6BT, United Kingdom.
Moritz MattheyWellcome Trust-MRC Cambridge Stem Cell Institute, Cambridge, CB2 1QR, United Kingdom.
Ragnhildur KáradóttirWellcome Trust-MRC Cambridge Stem Cell Institute, Cambridge, CB2 1QR, United Kingdom.
Louise WhiteleyDepartment of Neuroscience, Pharmacology and Physiology, University College London, London, WC1E 6BT, United Kingdom.
Linda H BergersenDepartment of Oral Biology, Brain and Muscle Energy Group, University of Oslo, Blindern, Oslo, N-0317, Norway.
William D RichardsonDepartment of Cell and Developmental Biology, Wolfson Institute for Biomedical Research, University College London, London, WC1E 6BT, United Kingdom.
David AttwellDepartment of Neuroscience, Pharmacology and Physiology, University College London, London, WC1E 6BT, United Kingdom.
University College London · GBWellcome/MRC Cambridge Stem Cell Institute · GBUniversity of Oslo · NO

Funding

Medical Research Council G0800575Medical Research Council G9708005Medical Research Council MC_PC_12009Wellcome Trust
6 · The paper itself

Abstract

Adjusting the thickness and internodal length of the myelin sheath is a mechanism for tuning the conduction velocity of axons to match computational needs. Interactions between oligodendrocyte precursor cells (OPCs) and developing axons regulate the formation of myelin around axons. We now show, using organotypic cerebral cortex slices from mice expressing eGFP in Sox10-positive oligodendrocytes, that endogenously released GABA, acting on GABA

Indexed as

AnimalsAxonsCell DifferentiationCell ProliferationCerebral CortexExcitatory Amino Acid AntagonistsGABA Agentsgamma-Aminobutyric AcidGene Expression RegulationMiceMice, TransgenicMyelin SheathNeuronsOligodendrogliaOrgan Culture TechniquesOrganogenesis2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxalineExcitatory Amino Acid AntagonistsGABA Agentsgamma-Aminobutyric AcidQuinoxalinesReceptors, GABASox10 protein, mouseSOXE Transcription FactorsTetrodotoxinGABAinternodemyelinationoligodendrocyteprecursorproliferation

Identifiers

PMID27796063
PMCPMC5214060
OpenAlexW2548711475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.