ArticleMaternal health, neonatology and perinatology2016
Timing and cause of perinatal mortality for small-for-gestational-age babies in South Africa: critical periods and challenges with detection.
Article in Maternal health, neonatology and perinatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 28 citations in OpenAlex.
- Situational Analysis on the Impact of Perinatal Deaths Among Bereaved Families in Ghana.Omega · 2025Article
- Causes of stillbirths at Kgapane hospital, Limpopo province.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2024Article
- Neonatal death audits at Kgapane Hospital, Limpopo province.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2023Article
- Implementation of continuous-wave Doppler ultrasound to detect the high-risk foetus in the low-risk mother: lessons from South Africa.BMC pregnancy and childbirth · 2023Article
- Preventing antenatal stillbirths: An innovative approach for primary health care.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2022Article
- Identifying the High-Risk Fetus in the Low-Risk Mother Using Fetal Doppler Screening.Global health, science and practice · 2022Article
- Association of mid-trimester maternal angiogenic biomarkers with small-for-gestational-age infants in an urban Zambian cohort: a nested case-control study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2022Article
- Article
- The prevalence of abnormal Doppler's of the umbilical artery in a low-risk pregnant population in South Africa.EClinicalMedicine · 2021Article
- Implementing antenatal care recommendations, South Africa.Bulletin of the World Health Organization · 2021Article
- The impact of implementing the 2016 WHO Recommendations on Antenatal Care for a Positive Pregnancy Experience on perinatal deaths: an interrupted time-series analysis in Mpumalanga province, South Africa.BMJ global health · 2020Article
- Prevalence, risk factors and consequences of newborns born small for gestational age: a multisite study in Nepal.BMJ paediatrics open · 2020Article
- Applying the international classification of diseases to perinatal mortality data, South Africa.Bulletin of the World Health Organization · 2018Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle information exists on timing and cause of death for small-for-gestational-age (SGA) babies in low-and-middle-income-countries (LMICs), despite evidence from high-income countries suggesting critical periods for SGA babies. This study explored the timing and cause of stillbirth and early neonatal mortality (END, <7 days) by small-for-gestational age in three provinces in South Africa. In South Africa, the largest category of perinatal deaths is unexplained stillbirth, of which up to one-quarter have intra-uterine growth restriction.
methodsSecondary analysis of the South African Perinatal Problems Identification Program (PPIP) database allowed for the analysis of gestational age at death and clinically confirmed diagnosis of stillbirth and early neonatal death (END) (>1000 g and >28 weeks) across gestation. Comparisons by province, size-for-gestational-age, gestational age groups, and maternal condition at death were performed. The provinces investigated were: Western Cape (fortnightly antenatal care visits from 32 to 38 weeks), Limpopo and Mpumalanga (no antenatal care visits between 32 to 38 weeks).
resultsThere were 528,727 births in the study period and 8111 stillbirths and 5792 early neonatal deaths. Similar timing of deaths across gestation was seen for the three provinces with the greatest proportion of deaths for SGA babies at 33-37 weeks (stillbirths 52.9 %; END 43.3 %;
conclusionThere was a peak in stillbirths for SGA babies 33-37 weeks in all provinces. Detecting SGA is further complicated as in most cases the mother is healthy. Further research into Umbiflow Doppler velocimetry use in low-risk populations is warranted and may be a viable strategy to increase current detection of SGA babies at risk of mortality in LMICs.
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