Evidence map›Paper›PMID 27795824›Full record

ArticleCell regeneration (London, England)2016

Loss of Mgat5a-mediated

Wuhong Pei, Sunny C Huang, Lisha Xu, Kade Pettie, María Laura Ceci, Mario Sánchez, Miguel L Allende, Shawn M Burgess

Open access · diamondAbstract read
In one paragraph

Article in Cell regeneration (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Mutation of the GDP-Fucose Biosynthesis GeneInternational journal of molecular sciences · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Wuhong PeiFunctional and Translation Genome Branch, National Human Genome Research Institute, 9000 Rockville Pike, Building 50, Room 5537, Bethesda, MD 20892 USA.
Sunny C HuangFunctional and Translation Genome Branch, National Human Genome Research Institute, 9000 Rockville Pike, Building 50, Room 5537, Bethesda, MD 20892 USA.
Lisha XuFunctional and Translation Genome Branch, National Human Genome Research Institute, 9000 Rockville Pike, Building 50, Room 5537, Bethesda, MD 20892 USA.
Kade PettieFunctional and Translation Genome Branch, National Human Genome Research Institute, 9000 Rockville Pike, Building 50, Room 5537, Bethesda, MD 20892 USA.
María Laura CeciCenter for Genome Regulation, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile.
Mario SánchezCenter for Genome Regulation, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile.
Miguel L AllendeCenter for Genome Regulation, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile.
Shawn M BurgessFunctional and Translation Genome Branch, National Human Genome Research Institute, 9000 Rockville Pike, Building 50, Room 5537, Bethesda, MD 20892 USA.
National Human Genome Research Institute · USUniversity of Chile · CL

Funding

Hearing regeneration in zebrafishZIAHG200386 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BURGESS, SHAWN M · 2012 to 2025
$12.5M
Intramural NIH HHS ZIA HG200386
6 · The paper itself

Abstract

backgroundWe are using genetics to identify genes specifically involved in hearing regeneration. In a large-scale genetic screening, we identified

methodsWe used a combination of mutant analysis in zebrafish and a hair cell regeneration assay to phenotype the loss of Mgat5a activity in zebrafish. We used pharmacological inhibition of

resultsWe found that

conclusionsThe findings from this study provide experimental evidence for the involvement of

Indexed as

CRISPR/Cas9mgat5aN-glycosylationRegenerationZebrafish

Identifiers

PMID27795824
PMCPMC5072312
OpenAlexW2539352230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.