ArticleMolecular and cellular biology1989
The chicken skeletal muscle alpha-actin promoter is tissue specific in transgenic mice.
Article in Molecular and cellular biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Skeletal Muscle-Restricted Expression of Human SOD1 in Transgenic Mice Causes a Fatal ALS-Like Syndrome.Frontiers in neurology · 2020Article
- Exogenous Expression of an Alternative Splicing Variant of Myostatin Prompts Leg Muscle Fiber Hyperplasia in Japanese Quail.International journal of molecular sciences · 2019Article
- Cellular prion protein regulates its own α-cleavage through ADAM8 in skeletal muscle.The Journal of biological chemistry · 2012Article
- Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice.Human molecular genetics · 2010Article
- Prions in skeletal muscle.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Restricting expression prolongs expression of foreign genes introduced into animals by retroviruses.Journal of virology · 2000Article
- Increased level and duration of expression in muscle by co-expression of a transactivator using plasmid systems.Gene therapy · 1999Article
- Strict regulation of c-Raf kinase levels is required for early organogenesis of the vertebrate inner ear.Oncogene · 1999Article
- Cell-specific transcription of the smooth muscle gamma-actin gene requires both positive- and negative-acting cis elements.Gene expression · 1998Article
- Distinct gene expression patterns in skeletal and cardiac muscle are dependent on common regulatory sequences in the MLC1/3 locus.Molecular and cellular biology · 1996Article
- Distinct regulatory elements control muscle-specific, fiber-type-selective, and axially graded expression of a myosin light-chain gene in transgenic mice.Molecular and cellular biology · 1996Article
- Expression of transduced genes in mice generated by infecting blastocysts with avian leukosis virus-based retroviral vectors.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Expression of carbonic anhydrase II (CA II) promoter-reporter fusion genes in multiple tissues of transgenic mice does not replicate normal patterns of expression indicating complexity of CA II regulation in vivo.Biochemical genetics · 1995Article
- Regulation of a muscle-specific transgene by retinoic acid.The Journal of cell biology · 1995Article
- A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup A avian leukosis virus-based retroviral vectors.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Regulation of expression of transgenes in developing fish.Transgenic research · 1993Article
- Elements responsible for hormonal control and tissue specificity of L-type pyruvate kinase gene expression in transgenic mice.Molecular and cellular biology · 1992Article
- Displacement of BrdUrd-induced YY1 by serum response factor activates skeletal alpha-actin transcription in embryonic myoblasts.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Appropriate in vivo expression of a muscle-specific promoter by using avian retroviral vectors for gene transfer [corrected].Journal of virology · 1992Article
- Activation of skeletal alpha-actin gene transcription: the cooperative formation of serum response factor-binding complexes over positive cis-acting promoter serum response elements displaces a negative-acting nuclear factor enriched in replicating myoblasts and nonmyogenic cells.Molecular and cellular biology · 1991Article
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Authors and funding
5 authors.
Funding
Abstract
We have generated transgenic mouse lines that carry the promoter region of the chicken skeletal muscle alpha (alpha sk) actin gene linked to the bacterial chloramphenicol acetyltransferase (CAT) gene. In adult mice, the pattern of transgene expression resembled that of the endogenous alpha sk actin gene. In most of the transgenic lines, high levels of CAT activity were detected in striated muscle (skeletal and cardiac) but not in the other tissues tested. In striated muscle, transcription of the transgene was initiated at the normal transcriptional start site of the chicken alpha sk actin gene. The region from nucleotides -191 to +27 of the chicken alpha sk actin gene was sufficient to direct the expression of CAT in striated muscle of transgenic mice. These observations suggest that the mechanism of tissue-specific actin gene expression is well conserved in higher vertebrate species.
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