Evidence map›Paper›PMID 27795590›Full record

ArticleRecent advances in phytochemistry2015

Nitrogen-Containing Constituents of Black Cohosh: Chemistry, Structure Elucidation, and Biological Activities.

Dejan Nikolić, David C Lankin, Tamara Cisowska, Shao-Nong Chen, Guido F Pauli, Richard B van Breemen

Abstract read
In one paragraph

Article in Recent advances in phytochemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Progress in the Study of Chemical Constituents ofInternational journal of molecular sciences · 2025
    Article
  3. Discovering the Untouched Perspective of Endangered North American HerbCombinatorial chemistry & high throughput screening · 2025
    Review
  4. Review of black cohosh-induced toxicity and adverse clinical effects.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Antioxidants (Basel, Switzerland) · 2022
    Article
  9. Protective Effect ofAnimals : an open access journal from MDPI · 2022
    Article
  10. Article
  11. Benefits of Black Cohosh (Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  12. Working with the natural complexity: Selection and characterization of black cohosh root extract for use in toxicology testing.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2022
    Article
  13. Article
  14. Evaluating Sufficient Similarity of Botanical Dietary Supplements: Combining Chemical and In Vitro Biological Data.Toxicological sciences : an official journal of the Society of Toxicology · 2019
    Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dejan NikolićUIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612-7231, USA.
David C LankinUIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612-7231, USA.
Tamara CisowskaUIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612-7231, USA.
Shao-Nong ChenUIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612-7231, USA.
Guido F PauliUIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612-7231, USA.
Richard B van BreemenUIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612-7231, USA.

Funding

Van Breemen: Project 3; Botanical Dietary Supplements - Metabolism and Safety in Women (Van Breemen)P50AT000155 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PAULI, GUIDO F · 1999 to 2019
$30.4M
NCCIH NIH HHS P50 AT000155
6 · The paper itself

Abstract

The roots/rhizomes of black cohosh (

Indexed as

5-HT7 receptorAcylated argininesAlkaloidsAporphine alkaloidsArginineBenzylisoquinoline alkaloidsBetainsBlack cohoshCholineCimicifuga racemosaCimipronidineCinnamidesGuanidino alkaloidsIndole alkaloidsIsoquinoline alkaloidsMagnoflorineMassBankMethylcimitrypazepineMonoamine oxidaseN-Feruloyl arginineN-Feruloyl tyramine glucosideNω-MethylserotoninPictet-Spengler reactionProtoberberine alkaloidsProtopineReticulineSalsolinolTrigonellineTriterpene glycosidesβ-Carbolinesγ-Guanidinobutyric acid

Identifiers

PMID27795590
PMCPMC5084696

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.