Evidence map›Paper›PMID 27795407›Full record

ReviewJournal of virology2017

Intrinsic and Innate Defenses of Neurons: Détente with the Herpesviruses.

Lynn W Enquist, David A Leib

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Antiviral responses in peripheral and brain neurons.Current opinion in immunology · 2025
    Review
  2. Review
  3. Host response to Aplysia Abyssovirus 1 in nervous system and gill.Developmental and comparative immunology · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Immunobiology of Varicella-Zoster Virus Infection.The Journal of infectious diseases · 2018
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Lynn W EnquistDepartment of Molecular Biology and Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA.
David A LeibDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA david.a.leib@dartmouth.edu.
Dartmouth College · USPrinceton University · US

Funding

VIral and host mechanisms that tilt the HSV lytic/latent balanceP01AI098681 · NIAID · HARVARD MEDICAL SCHOOL · PI PESOLA, JEAN M · 2013 to 2023
$19.2M
VIRAL & HOST FACTORS IN HERPETIC REACTIVATIONR01EY009083 · NEI · WASHINGTON UNIVERSITY · PI David A Leib · 1992 to 2026
$10.3M
Genetic Analysis of Herpesvirus Tropism and VirulenceR37NS033506 · NINDS · PRINCETON UNIVERSITY · PI ENQUIST, LYNN W. · 2005 to 2020
$4.1M
GENETIC ANALYSIS OF HERPESVIRUS TROPISM AND VIRULENCER01NS033506 · NINDS · PRINCETON UNIVERSITY · PI ENQUIST, LYNN W. · 1995 to 2016
$3.7M
Neuronal Spread of Herpesvirus InfectionR01NS060699 · NINDS · PRINCETON UNIVERSITY · PI ENQUIST, LYNN W. · 2008 to 2017
$3.6M
NEI NIH HHS R01 EY009083NIAID NIH HHS P01 AI098681NINDS NIH HHS R01 NS033506NINDS NIH HHS R01 NS060699NINDS NIH HHS R37 NS033506
6 · The paper itself

Abstract

Neuroinvasive herpesviruses have evolved to efficiently infect and establish latency in neurons. The nervous system has limited capability to regenerate, so immune responses therein are carefully regulated to be nondestructive, with dependence on atypical intrinsic and innate defenses. In this article we review studies of some of these noncanonical defense pathways and how herpesvirus gene products counter them, highlighting the contributions that primary neuronal in vitro models have made to our understanding of this field.

Indexed as

Gene SilencingImmune EvasionAutophagyAxonal TransportCo-Repressor ProteinsHerpesviridaeHistone DeacetylasesHistone DemethylasesHumansImmediate-Early ProteinsImmunity, InnateInterferonsMicroRNAsNerve Tissue ProteinsNeuronsSignal TransductionCo-Repressor ProteinsHistone DeacetylasesHistone DemethylasesImmediate-Early ProteinsInterferonsKDM1A protein, humanMicroRNAsMIRN138 microRNA, humanNerve Tissue ProteinsRCOR1 protein, humanUbiquitin-Protein LigasesVmw110 protein, Human herpesvirus 1herpesvirusesinnate immunityintrinsic immunityneuroimmunologyneurotropic viruses

Identifiers

PMID27795407
PMCPMC5165195
OpenAlexW2533110981

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.