Evidence map›Paper›PMID 27795371›Full record

ArticleAntimicrobial agents and chemotherapy2017

In Vitro Activities of Novel Azole Compounds ATTAF-1 and ATTAF-2 against Fluconazole-Susceptible and -Resistant Isolates of Candida Species.

Hamed Fakhim, Saeed Emami, Afsane Vaezi, Seyedeh Mahdieh Hashemi, Leila Faeli, Kambiz Diba, Eric Dannaoui, Hamid Badali

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Antifungal Susceptibility ofIranian journal of public health · 2018
    Article
  12. Article
  13. Antimicrobial agents and chemotherapy · 2017
    Article
  14. Caspofungin-Non-SusceptibleIranian journal of public health · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hamed FakhimStudent Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Saeed EmamiDepartment of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Afsane VaeziStudent Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Seyedeh Mahdieh HashemiDepartment of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Leila FaeliStudent Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Kambiz DibaCellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Eric DannaouiUniversité Paris-Descartes, Faculté de Médecine, APHP, Hôpital Européen Georges Pompidou, Unité de Parasitologie-Mycologie, Service de Microbiologie, Paris, France.ORCID 0000-0002-2817-3830
Hamid BadaliDepartment of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran badalii@yahoo.com.ORCID 0000-0002-6010-8414

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The in vitro activities of two novel azole compounds (aryl-1,2,4-triazol-3-ylthio analogues of fluconazole [ATTAFs]) and five comparator antifungal agents against 52 clinical Candida isolates from 5 different species were determined. The novel azole compounds had the lowest geometric mean MICs, followed by fluconazole. Moreover, combinations of these compounds with fluconazole exhibited synergistic effects against fluconazole-susceptible (22 of 23 isolates), fluconazole-susceptible dose-dependent (10 of 13 isolates), and fluconazole-resistant (1 of 16 isolates) Candida isolates.

Indexed as

Antifungal AgentsAzolesCandidaDrug Resistance, FungalFluconazoleMicrobial Sensitivity TestsTriazolesAntifungal AgentsAzolesFluconazoleTriazolesCandida speciesIn vitro susceptibilitytriazole derivatives

Identifiers

PMID27795371
PMCPMC5192144

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.