Evidence map›Paper›PMID 27795366›Full record

ArticleInfection and immunity2017

Gamma Interferon-Regulated Chemokines in Leishmania donovani Infection in the Liver.

Henry W Murray, Andrew D Luster, Hua Zheng, Xiaojing Ma

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  4. Review
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  9. Article
  10. Targeting IL-27 and/or IL-10 in Experimental Murine Visceral Leishmaniasis.The American journal of tropical medicine and hygiene · 2020
    Article
  11. Triterpenoids Extracted FromFrontiers in microbiology · 2020
    Article
  12. Article
  13. Cutting Edge: Bacillus Calmette-Guérin-Induced T Cells ShapeJournal of immunology (Baltimore, Md. : 1950) · 2019
    Article
  14. Article
  15. RNA-Seq Revealed Expression of Many Novel Genes Associated WithFrontiers in cellular and infection microbiology · 2019
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Henry W MurrayDepartment of Medicine, Weill Cornell Medical College, New York, New York, USA hwmurray@med.cornell.edu.
Andrew D LusterCenter for Immunology and Inflammatory Diseases, Division of Rheumatology & Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Hua ZhengShanghai Jiaotong University School of Life Science and Biotechnology, Shanghai, China.
Xiaojing MaShanghai Jiaotong University School of Life Science and Biotechnology, Shanghai, China.
Shanghai Jiao Tong University · CNCornell University · USHarvard University · US

Funding

IP 10--ITS ROLE IN INFLAMMATION AND CANCER THERAPYR01CA069212 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI LUSTER, ANDREW D · 1996 to 2014
$5.6M
Immunochemotherapy in Visceral LeishmaniasisR01AI083219 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI MURRAY, HENRY W. · 2010 to 2014
$2.4M
NCI NIH HHS R01 CA069212NIAID NIH HHS R01 AI083219
6 · The paper itself

Abstract

In the livers of C57BL/6 mice, gamma interferon (IFN-γ) controls intracellular Leishmania donovani infection and the efficacy of antimony (Sb) chemotherapy. Since both responses usually correlate with granulomatous inflammation, we tested six prominently expressed, IFN-γ-regulated chemokines-CXCL9, CXCL10, CXCL13, CXCL16, CCL2, and CCL5-for their roles in (i) mononuclear cell recruitment and granuloma assembly and maturation, (ii) initial control of infection and self-cure, and (iii) responsiveness to Sb treatment. Together, the results for the L. donovani-infected livers of chemokine-deficient mice (CXCR6

Indexed as

AnimalsChemokinesFemaleGranulomaInterferon-gammaLeishmania donovaniLeishmaniasis, VisceralLiverMiceMice, Inbred C57BLT-LymphocytesChemokinesInterferon-gammachemokinesgranulomaLeishmania donovanipentavalent antimonyvisceral leishmaniasis

Identifiers

PMID27795366
PMCPMC5203646
OpenAlexW2533908296

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.