Evidence map›Paper›PMID 27795360›Full record

ArticleInfection and immunity2017

Local Induction of B Cell Interleukin-10 Competency Alleviates Inflammation and Bone Loss in Ligature-Induced Experimental Periodontitis in Mice.

Pei Yu, Yang Hu, Zhiqiang Liu, Toshihisa Kawai, Martin A Taubman, Wei Li, Xiaozhe Han

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
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  17. MicroRNA-146a regulates the production of cytokines in lymphocytes stimulated byHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Pei YuState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Yang HuThe Forsyth Institute, Department of Immunology and Infectious Diseases, Cambridge, Massachusetts, USA.
Zhiqiang LiuThe Forsyth Institute, Department of Immunology and Infectious Diseases, Cambridge, Massachusetts, USA.
Toshihisa KawaiThe Forsyth Institute, Department of Immunology and Infectious Diseases, Cambridge, Massachusetts, USA.
Martin A TaubmanThe Forsyth Institute, Department of Immunology and Infectious Diseases, Cambridge, Massachusetts, USA.
Wei LiState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Xiaozhe HanThe Forsyth Institute, Department of Immunology and Infectious Diseases, Cambridge, Massachusetts, USA xhan@forsyth.org.
Sichuan University · CNBeijing Chao-Yang Hospital · CN

Funding

Regulatory B Cells in the Amelioration of Immune-Mediated Periodontal DiseaseR01DE025255 · NIDCR · NOVA SOUTHEASTERN UNIVERSITY · PI HAN, XIAOZHE · 2015 to 2025
$5.8M
Regulatory B cells in the amelioration of immune-mediated periodontal diseaseR56DE023807 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI HAN, XIAOZHE · 2014 to 2014
$476k
NIDCR NIH HHS R01 DE025255NIDCR NIH HHS R56 DE023807
6 · The paper itself

Abstract

Interleukin-10 (IL-10)-producing B cells (B10 cells) play a critical role in the immune system balance by negatively regulating inflammatory responses. This study was conducted to determine the effect of local B10 cell induction on periodontal inflammation and bone loss in ligature-induced experimental periodontitis in vivo Purified spleen B cells from C57BL/6J mice (8 to 10 weeks old) were cultured with CD40 ligand (CD40L) and the Toll-like receptor 9 (TLR9) agonist cytidine-phosphate-guanosine oligodeoxynucleotide (CpG) to determine effective IL-10 induction in vitro Silk ligatures (size 7-0) were tied around the mouse maxillary second molars on day 0, followed by the injection of CD40L and CpG into the palatal gingiva on days 3, 6, and 9. All the mice were sacrificed, and samples were collected on day 14. CD40L and CpG significantly increased the level of IL-10 production by B cells in vitro, although the frequencies of CD1d

Indexed as

Alveolar Bone LossAnimalsB-LymphocytesBone Diseases, MetabolicCD40 LigandDisease Models, AnimalGingivaInflammationInterleukin-10Interleukin-1betaLigationMiceMice, Inbred C57BLOligodeoxyribonucleotidesPeriodontitisPorphyromonas gingivalisCD40 LigandIL10 protein, mouseInterleukin-10Interleukin-1betaOligodeoxyribonucleotidesRANK LigandToll-Like Receptor 9B cellsbone resorptionIL-10periodontitisRANKL

Identifiers

PMID27795360
PMCPMC5203658
OpenAlexW2532558743

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.