Evidence map›Paper›PMID 27795341›Full record

ArticleJournal of clinical microbiology2017

Serology Enhances Molecular Diagnosis of Respiratory Virus Infections Other than Influenza in Children and Adults Hospitalized with Community-Acquired Pneumonia.

Yange Zhang, Senthilkumar K Sakthivel, Anna Bramley, Seema Jain, Amber Haynes, James D Chappell, Weston Hymas, Noel Lenny, Anami Patel, Chao Qi and 13 more

Registry-linked trialOpen access · bronzeAbstract readComparative StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06286007 (Prevalence and Impact of Pertussis and RSV on Asthma Severity and Control), which is not on this map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06286007 unknown statusnot on this mapstarted 2023, after this paper: background citation

Prevalence and Impact of Pertussis and RSV on Asthma Severity and Control

Typeobservational_patient_registrySponsorHospital Clinico Universitario de SantiagoRan2023 to 2026Enrolled784ConditionsAsthma, Pertussis, RSV InfectionArmsPCR
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Burden of Respiratory Viruses in Children Less Than 2 Years Old in a Community-based Longitudinal US Birth Cohort.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Parainfluenza Virus Types 1-3 Infections Among Children and Adults Hospitalized With Community-acquired Pneumonia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 7 institutions in 1 country.

Yange ZhangCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Senthilkumar K SakthivelCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Anna BramleyCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Seema JainCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
Amber HaynesCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
James D ChappellVanderbilt University School of Medicine, Nashville, Tennessee, USA.
Weston HymasUniversity of Utah Health Sciences Center, Salt Lake City, Utah, USA.
Noel LennyLe Bonheur Children's Hospital, Memphis, Tennessee, USA.
Anami PatelLe Bonheur Children's Hospital, Memphis, Tennessee, USA.
Chao QiNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Krow AmpofoUniversity of Utah Health Sciences Center, Salt Lake City, Utah, USA.
Sandra R ArnoldLe Bonheur Children's Hospital, Memphis, Tennessee, USA.
Wesley H SelfVanderbilt University School of Medicine, Nashville, Tennessee, USA.
Derek J WilliamsVanderbilt University School of Medicine, Nashville, Tennessee, USA.
David HillyardUniversity of Utah Health Sciences Center, Salt Lake City, Utah, USA.
Evan J AndersonEmory University School of Medicine, Atlanta, Georgia, USA.
Carlos G GrijalvaVanderbilt University School of Medicine, Nashville, Tennessee, USA.
Yuwei ZhuVanderbilt University School of Medicine, Nashville, Tennessee, USA.
Richard G WunderinkNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Kathryn M EdwardsVanderbilt University School of Medicine, Nashville, Tennessee, USA.
Andrew T PaviaUniversity of Utah Health Sciences Center, Salt Lake City, Utah, USA.
Jonathan A McCullersLe Bonheur Children's Hospital, Memphis, Tennessee, USA.
Dean D ErdmanCenters for Disease Control and Prevention, Atlanta, Georgia, USA dde1@cdc.gov.
Centers for Disease Control and Prevention · USVanderbilt University · USUniversity of Utah · USLe Bonheur Children's Hospital · USNorthwestern University · USUniversity of Tennessee Health Science Center · USEmory University · US

Funding

Opioid selection and the risk of serious infections in older adultsR01AG043471 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GRIJALVA, CARLOS G · 2013 to 2017
$2.3M
Salivary Cortisol as a Marker of Community-Acquired Pneumonia Severity in AdultsK23GM110469 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SELF, WESLEY H · 2015 to 2018
$683k
NIA NIH HHS R01 AG043471NIGMS NIH HHS K23 GM110469
6 · The paper itself

Abstract

Both molecular and serological assays have been used previously to determine the etiology of community-acquired pneumonia (CAP). However, the extent to which these methods are correlated and the added diagnostic value of serology for respiratory viruses other than influenza virus have not been fully evaluated. Using data from patients enrolled in the Centers for Disease Control and Prevention (CDC) Etiology of Pneumonia in the Community (EPIC) study, we compared real-time reverse transcription-PCR (RT-PCR) and serology for the diagnosis of respiratory syncytial virus (RSV), human metapneumovirus (HMPV), parainfluenza virus 1 to 3 (PIV1, PIV2, and PIV3), and adenovirus (AdV) infections. Of 5,126 patients enrolled, RT-PCR and serology test results were available for 2,023, including 1,087 children below the age of 18 years and 936 adults. For RSV, 287 (14.2%) patients were positive by RT-PCR and 234 (11.6%) were positive by serology; for HMPV, 172 (8.5%) tested positive by RT-PCR and 147 (7.3%) by serology; for the PIVs, 94 (4.6%) tested positive by RT-PCR and 92 (4.6%) by serology; and for AdV, 111 (5.5%) tested positive by RT-PCR and 62 (3.1%) by serology. RT-PCR provided the highest number of positive detections overall, but serology increased diagnostic yield for RSV (by 11.8%), HMPV (by 25.0%), AdV (by 32.4%), and PIV (by 48.9%). The method concordance estimated by Cohen's kappa coefficient (κ) ranged from good (for RSV; κ = 0.73) to fair (for AdV; κ = 0.27). Heterotypic seroresponses observed between PIVs and persistent low-level AdV shedding may account for the higher method discordance observed with each of these viruses. Serology can be a helpful adjunct to RT-PCR for research-based assessment of the etiologic contribution of respiratory viruses other than influenza virus to CAP.

Indexed as

AdolescentAdultAgedAged, 80 and overChildChild, PreschoolCommunity-Acquired InfectionsFemaleHospitalizationHumansInfantInfant, NewbornMaleMiddle AgedMolecular Diagnostic TechniquesPneumonia, Viralcommunity-acquired pneumoniaPCR assaysPCR assays and serologyrespiratory virus infectionsserology

Identifiers

PMID27795341
PMCPMC5228265
OpenAlexW2535521421

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.