Evidence map›Paper›PMID 27795302›Full record

ArticleClinical and vaccine immunology : CVI2017

Identification of a T-Cell Epitope That Is Globally Conserved among Outer Membrane Proteins (OMPs) OMP7, OMP8, and OMP9 of Anaplasma marginale Strains and with OMP7 from the A. marginale subsp. centrale Vaccine Strain.

James R Deringer, Elkin G Forero-Becerra, Massaro W Ueti, Joshua E Turse, James E Futse, Susan M Noh, Guy H Palmer, Wendy C Brown

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Identification of a DRB3*011:01-restricted CD4Frontiers in immunology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

James R DeringerDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.
Elkin G Forero-BecerraDepartment of Veterinary Medicine, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Massaro W UetiAnimal Diseases Research Unit, Agricultural Research Service, U.S. Department of Agriculture, Pullman, Washington, USA.
Joshua E TurseDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.
James E FutseDepartment of Animal Science, College of Basic and Applied Sciences, University of Ghana, Legon, Ghana.
Susan M NohAnimal Diseases Research Unit, Agricultural Research Service, U.S. Department of Agriculture, Pullman, Washington, USA.
Guy H PalmerDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.
Wendy C BrownDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA wbrown@vetmed.wsu.edu.
Washington State University · USAgricultural Research Service · USUnited States Department of Agriculture · USUniversidade Federal de Viçosa · BRUniversity of Ghana · GH

Funding

Infectious Diseases and Microbial Immunology Training ProgramT32AI007025 · NIAID · WASHINGTON STATE UNIVERSITY · PI Thomas H KAWULA, M KARIUKI NJENGA · 1985 to 2026
$7.4M
Antigenic variation in microbial transmissionR37AI044005 · NIAID · WASHINGTON STATE UNIVERSITY · PI PALMER, GUY HUGHES · 2009 to 2018
$3.3M
Immunogenicity of the Type IV Secretin SystemR01AI053692 · NIAID · WASHINGTON STATE UNIVERSITY · PI BROWN, WENDY CATHERINE · 2003 to 2012
$3.3M
Antigenic variation in rickettsial transmissionR01AI044005 · NIAID · WASHINGTON STATE UNIVERSITY · PI PALMER, GUY HUGHES · 1999 to 2008
$2.4M
NIAID NIH HHS R01 AI044005NIAID NIH HHS R01 AI053692NIAID NIH HHS R37 AI044005NIAID NIH HHS T32 AI007025Wellcome Trust
6 · The paper itself

Abstract

Within the protective outer membrane (OM) fraction of Anaplasma marginale, several vaccine candidates have emerged, including a family of OM proteins (OMPs) 7 to 9, which share sequence identity with each other and with the single protein OMP7 in the vaccine strain A. marginale subsp. centrale. A. marginale OMPs 7 to 9 are logical vaccine candidates because they are surface exposed, present in the OM immunogen and protective cross-linked OM proteins, recognized by immune serum IgG2 and T cells in cattle immunized with OM, and recognized by immune serum IgG2 from cattle immunized with the A. centrale vaccine strain. We report the identification of a globally conserved 9-amino-acid T-cell epitope FLLVDDAI/VV shared between A. centrale vaccine strain OMP7 and the related A. marginale OMPs 7 to 9, where position 8 of the peptide can be isoleucine or valine. The epitope is conserved in American A. marginale strains, in the Australia Gypsy Plains strain, and in multiple field isolates from Ghana. This epitope, together with additional T-cell epitopes that are present within these proteins, should be considered for inclusion in a multivalent vaccine for A. marginale that can provide protection against disease caused by globally distributed bacterial strains.

Indexed as

Conserved SequenceAmericasAnaplasma marginaleAnimalsAustraliaBacterial Outer Membrane ProteinsEpitopes, T-LymphocyteGhanaBacterial Outer Membrane ProteinsEpitopes, T-LymphocyteAnaplasma centraleAnaplasma marginaleouter membrane protein 7outer membrane protein 8outer membrane protein 9T-cell epitopes

Identifiers

PMID27795302
PMCPMC5216429
OpenAlexW2541370469

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.