Evidence map›Paper›PMID 27794691›Full record

ArticleThe American journal of psychiatry2017

The Origins of Cognitive Deficits in Victimized Children: Implications for Neuroscientists and Clinicians.

Andrea Danese, Terrie E Moffitt, Louise Arseneault, Ben A Bleiberg, Perry B Dinardo, Stephanie B Gandelman, Renate Houts, Antony Ambler, Helen L Fisher, Richie Poulton and 1 more

Open access · bronzeAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 8 pooled it
24.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 8 syntheses or guidelines pooled it, 184 citations in OpenAlex.

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  16. Flourishing in Early Adulthood Among Victimized Children: A Longitudinal Cohort Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026
    Article
  17. Observational
  18. Article
  19. Synergistic pathways to psychosis: understanding developmental risk and resilience factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  20. Article

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Andrea DaneseFrom the MRC Social, Genetic, and Developmental Psychiatry Centre and the Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, De Crespigny Park, London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience and the Department of Psychiatry and Behavioral Sciences, Duke University, Durham, N.C.; and the Department of Psychology, University of Otago, Dunedin, New Zealand.
Terrie E MoffittFrom the MRC Social, Genetic, and Developmental Psychiatry Centre and the Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, De Crespigny Park, London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience and the Department of Psychiatry and Behavioral Sciences, Duke University, Durham, N.C.; and the Department of Psychology, University of Otago, Dunedin, New Zealand.
Louise ArseneaultFrom the MRC Social, Genetic, and Developmental Psychiatry Centre and the Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, De Crespigny Park, London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience and the Department of Psychiatry and Behavioral Sciences, Duke University, Durham, N.C.; and the Department of Psychology, University of Otago, Dunedin, New Zealand.
Ben A BleibergFrom the MRC Social, Genetic, and Developmental Psychiatry Centre and the Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, De Crespigny Park, London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience and the Department of Psychiatry and Behavioral Sciences, Duke University, Durham, N.C.; and the Department of Psychology, University of Otago, Dunedin, New Zealand.
Perry B DinardoFrom the MRC Social, Genetic, and Developmental Psychiatry Centre and the Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, De Crespigny Park, London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience and the Department of Psychiatry and Behavioral Sciences, Duke University, Durham, N.C.; and the Department of Psychology, University of Otago, Dunedin, New Zealand.
Stephanie B GandelmanFrom the MRC Social, Genetic, and Developmental Psychiatry Centre and the Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, De Crespigny Park, London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience and the Department of Psychiatry and Behavioral Sciences, Duke University, Durham, N.C.; and the Department of Psychology, University of Otago, Dunedin, New Zealand.
Renate HoutsFrom the MRC Social, Genetic, and Developmental Psychiatry Centre and the Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, De Crespigny Park, London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience and the Department of Psychiatry and Behavioral Sciences, Duke University, Durham, N.C.; and the Department of Psychology, University of Otago, Dunedin, New Zealand.
Antony AmblerFrom the MRC Social, Genetic, and Developmental Psychiatry Centre and the Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, De Crespigny Park, London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience and the Department of Psychiatry and Behavioral Sciences, Duke University, Durham, N.C.; and the Department of Psychology, University of Otago, Dunedin, New Zealand.
Helen L FisherFrom the MRC Social, Genetic, and Developmental Psychiatry Centre and the Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, De Crespigny Park, London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience and the Department of Psychiatry and Behavioral Sciences, Duke University, Durham, N.C.; and the Department of Psychology, University of Otago, Dunedin, New Zealand.
Richie PoultonFrom the MRC Social, Genetic, and Developmental Psychiatry Centre and the Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, De Crespigny Park, London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience and the Department of Psychiatry and Behavioral Sciences, Duke University, Durham, N.C.; and the Department of Psychology, University of Otago, Dunedin, New Zealand.
Avshalom CaspiFrom the MRC Social, Genetic, and Developmental Psychiatry Centre and the Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, De Crespigny Park, London; the National and Specialist Clinic for Child Traumatic Stress and Anxiety Disorders, South London and Maudsley NHS Foundation Trust, London; the Department of Psychology and Neuroscience and the Department of Psychiatry and Behavioral Sciences, Duke University, Durham, N.C.; and the Department of Psychology, University of Otago, Dunedin, New Zealand.
South London and Maudsley NHS Foundation Trust · GB

Funding

STALLARD Admin Supp: Predicting Future Care Needs and Costs for Individual Medicare Enrollees with Incident Suspected Alzheimer's DiseaseP30AG034424 · NIA · DUKE UNIVERSITY · PI SCOTT M. LYNCH · 2009 to 2026
$12.2M
Quantifying Individual Differences in Midlife Structural Brain Integrity Associated with Later AD/ADRD RiskR01AG049789 · NIA · DUKE UNIVERSITY · PI AHMAD R. HARIRI, TERRIE E MOFFITT · 2015 to 2026
$10.6M
Is mental disorder a preventable cause of age-related disease? The Dunedin Study.R01AG032282 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2009 to 2025
$9.5M
Neuropsychological and genomic signatures of violence exposure in childhoodR01HD077482 · NICHD · DUKE UNIVERSITY · PI CASPI, AVSHALOM · 2013 to 2018
$2.8M
Generating new knowledge to support reversibility interventionsR01AG048895 · NIA · DUKE UNIVERSITY · PI MOFFITT, TERRIE E · 2014 to 2015
$311k
Medical Research Council MR/P005918/1NIA NIH HHS P30 AG034424NIA NIH HHS R01 AG032282NIA NIH HHS R01 AG048895NIA NIH HHS R01 AG049789NICHD NIH HHS R01 HD077482
6 · The paper itself

Abstract

objectiveIndividuals reporting a history of childhood violence victimization have impaired brain function. However, the clinical significance, reproducibility, and causality of these findings are disputed. The authors used data from two large cohort studies to address these research questions directly.

methodThe authors tested the association between prospectively collected measures of childhood violence victimization and cognitive functions in childhood, adolescence, and adulthood among 2,232 members of the U.K. E-Risk Study and 1,037 members of the New Zealand Dunedin Study who were followed up from birth until ages 18 and 38 years, respectively. Multiple measures of victimization and cognition were used, and comparisons were made of cognitive scores for twins discordant for victimization.

resultsIndividuals exposed to childhood victimization had pervasive impairments in clinically relevant cognitive functions, including general intelligence, executive function, processing speed, memory, perceptual reasoning, and verbal comprehension in adolescence and adulthood. However, the observed cognitive deficits in victimized individuals were largely explained by cognitive deficits that predated childhood victimization and by confounding genetic and environmental risks.

conclusionsFindings from two population-representative birth cohorts totaling more than 3,000 individuals and born 20 years and 20,000 km apart suggest that the association between childhood violence victimization and later cognition is largely noncausal, in contrast to conventional interpretations. These findings support the adoption of a more circumspect approach to causal inference in the neuroscience of stress. Clinically, cognitive deficits should be conceptualized as individual risk factors for victimization as well as potential complicating features during treatment.

Indexed as

AdolescentAdultCausalityChild AbuseChild, PreschoolCognitive DysfunctionCohort StudiesConfounding Factors, EpidemiologicCrime VictimsDiseases in TwinsFemaleGene-Environment InteractionHumansIntelligenceLongitudinal StudiesMaleChild MaltreatmentCognitionExecutive FunctionIQStressVictimization

Identifiers

PMID27794691
PMCPMC5378606
OpenAlexW2541785732

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.