Evidence map›Paper›PMID 27794252›Full record

Trial reportJournal of affective disorders2017

A naturalistic, multi-site study of repetitive transcranial magnetic stimulation therapy for depression.

Stephan F Taylor, Mahendra T Bhati, Marc J Dubin, John M Hawkins, Sarah H Lisanby, Oscar Morales, Irving M Reti, Shirlene Sampson, E Baron Short, Catherine Spino and 2 more

Abstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 1 country.

Stephan F TaylorUniversity of Michigan, Ann Arbor, MI, USA. Electronic address: sftaylor@umich.edu.
Mahendra T BhatiUniversity of Pennsylvania, Philadelphia, PA, USA.
Marc J DubinWeill Cornell Medical College, New York, USA.
John M HawkinsLinder Center/University of Cincinnati, Cincinnati, OH, USA.
Sarah H LisanbyDuke University, Durham, NC, USA; National Institute of Mental Health, USA.
Oscar MoralesMcLean Hospital, Harvard University, Cambridge, MA, USA.
Irving M RetiJohns Hopkins University, Baltimore, MD, USA.
Shirlene SampsonMayo Clinic, Rochester, MN, USA.
E Baron ShortMedical University of South Carolina, Charleston, SC, USA.
Catherine SpinoUniversity of Michigan, Ann Arbor, MI, USA.
Kuanwong WatcharotoneUniversity of Michigan, Ann Arbor, MI, USA.
Jesse WrightUniversity of Louisville, Louisville, KY, USA.
University of Michigan–Ann Arbor · USCornell University · USHarvard University · USJohns Hopkins University · USMayo Clinic in Arizona · USMedical University of South Carolina · USNational Institute of Mental Health · USUniversity of Cincinnati · USUniversity of Louisville · USUniversity of Pennsylvania · US

Funding

Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Non-invasive Neuromodulation Unit (NNU)ZIAMH002955 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI ZARATE, CARLOS · 2016 to 2025
$40.3M
NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR002240NCATS NIH HHS UL1 TR002384
6 · The paper itself

Abstract

backgroundRepetitive transcranial magnetic stimulation (rTMS) was approved in 2008 in the United States, and there are relatively few studies describing its use in regular clinical practice since approval.

methodsFrom April 2011 to October 2014, ten sites within the National Network of Depression Centers (NNDC) provided data on 62 evaluable patients with a depressive episode. Treatment was determined naturalistically. Response was assessed by the Quick Inventory of Depressive Symptoms, Self-Report (QIDS-SR) as the primary outcome, and the Patient Health Questionnaire-9 (PHQ-9) and the clinician-rated Clinical Global Impression (CGI) as secondary depression measures.

resultsEnrolled patients exhibited significant treatment resistance, with 70.2% reporting more than 4 prior depressive episodes. Most patients received treatment with standard parameters (10Hz over the left dorsolateral prefrontal cortex), although 22.6% of the patients received 1 or 5Hz stimulation at some point. Over 6 weeks of treatment, response and remission rates were 29.4% and 5.9%, respectively, for the QIDS-SR; 39.2% and 15.7%, respectively, for the PHQ-9; and 50.9% and 17.9%, respectively, for the CGI. Moderator analyses revealed no effect of prior depressive episodes, history of ECT or gender, although early life stress predicted a better response to rTMS therapy. LIMITATIONS: The study was an open-label, registry trial, with relatively coarse clinical data, reflecting practice only in academic, depression-specialty centers. Because of the relatively small size and heterogeneity of the sample, type 2 errors are possible and positive findings are in need of replication.

conclusionrTMS demonstrates effectiveness in clinical practice within the NNDC, although remission rates appear slightly lower in comparison with other recent naturalistic studies.

Indexed as

Transcranial Magnetic StimulationAcademic Medical CentersAdultDepressive DisorderFemaleHumansMaleMiddle AgedPsychiatric Status Rating ScalesRegression AnalysisRemission InductionSelf ReportTreatment OutcomeBrainDorsolateral prefrontal cortexNeuromodulationRegistry

Identifiers

PMID27794252
PMCPMC5550826
OpenAlexW2533234549

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.