Evidence map›Paper›PMID 27794094›Full record

ArticleTransactions of the Royal Society of Tropical Medicine and Hygiene2016

Neurocysticercosis in Bhutan: a cross-sectional study in people with epilepsy.

Kate Brizzi, Sonam Pelden, Tshokey Tshokey, Damber K Nirola, Megan B Diamond, Joshua P Klein, Lhab Tshering, Sonam Deki, Dechen Nidup, Veronica Bruno and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Cerebral cysticercosis in a wild Bengal tigerInternational journal for parasitology. Parasites and wildlife · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 4 countries.

Kate BrizziMassachusetts General Hospital, Boston, MA, USA.
Sonam PeldenDepartment of Laboratory Medicine, Jigme Dorji Wangchuck National Referral Hospital, Bhutan.
Tshokey TshokeyDepartment of Laboratory Medicine, Jigme Dorji Wangchuck National Referral Hospital, Bhutan.
Damber K NirolaDepartment of Psychiatry, Jigme Dorji Wangchuck National Referral Hospital, Bhutan.
Megan B DiamondMassachusetts General Hospital, Boston, MA, USA.
Joshua P KleinBrigham and Women's Hospital, Boston, MA, USA.
Lhab TsheringDepartment of Psychiatry, Jigme Dorji Wangchuck National Referral Hospital, Bhutan.
Sonam DekiDepartment of Psychiatry, Jigme Dorji Wangchuck National Referral Hospital, Bhutan.
Dechen NidupDepartment of Radiology, Jigme Dorji Wangchuck National Referral Hospital, Bhutan.
Veronica BrunoMassachusetts General Hospital, Boston, MA, USA.
Pierre DornyDepartment of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Hector Hugo GarciaCysticercosis Unit, Instituto de Ciencias Neurologicas, Department of Microbiology, Universidad Peruana Cayetan Heredia, Lima, Peru.
Farrah J MateenMassachusetts General Hospital, Boston, MA, USA fmateen@partners.org.
Bhutan Epilepsy Project
Teaching Hospital Kandy · LKMassachusetts General Hospital · USHarvard University · USInstituut voor Tropische Geneeskunde · BEUniversidad Peruana Cayetano Heredia · PE

Funding

Wellcome Trust 091077
6 · The paper itself

Abstract

backgroundWe sought to provide an assessment of the burden of neurocysticercosis among people with epilepsy (PWE) in Bhutan and evaluate the yield of various tests for Taenia solium.

methodsPWE were enrolled at the National Referral Hospital in Thimphu (2014-2015). Serum was tested for anti-Taenia solium IgG using ELISA (Ab-ELISA), enzyme-linked immunoelectrotransfer blot (EITB), and parasite antigen. Results were compared to brain MRI. Participants were categorized as definite neurocysticercosis (MRI and EITB positive), probable neurocysticercosis (MRI or EITB positive), or without neurocysticercosis. Logistic regression models were constructed to explore clinicodemographic associations.

resultsThere were 12/205 (6%, 95% CI 2%, 9%) definite and 40/205 (20%, 95% CI 14%, 25%) probable neurocysticercosis cases. 25/205 (12%) with positive EITB did not have neurocysticercosis on MRI, and 15/205 (7%) participants with positive MRI had negative EITB. Participants with neurocysticercosis-suggestive lesions on MRI had an average of 1.2 cysts (parenchymal 26/27; nodular/calcified stage 21/27). In a multivariable analysis, present age (OR 1.05, 95% CI 1.01,1.09, p=0.025) was positively associated with (combined probable or definite) neurocysticercosis while mesial temporal sclerosis on MRI (OR 0.294, 95% CI 0.144, 0.598, p=0.001) was negatively associated.

conclusionsNeurocysticercosis was associated with 6-25% of epilepsy in a Bhutanese cohort. Combining EITB and MRI would aid the diagnosis of neurocysticercosis among PWE since no test identified all cases.

Indexed as

Magnetic Resonance ImagingAdultAnimalsAntibodies, HelminthAntigens, HelminthBhutanCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayEpilepsyFemaleFollow-Up StudiesHealth Knowledge, Attitudes, PracticeHumansImmunoblottingMaleNeurocysticercosisAntibodies, HelminthAntigens, HelminthBhutanEnzyme-linked immunoelectrotransfer blotEpilepsyMagnetic resonance imagingNeurocysticercosisSeizure

Identifiers

PMID27794094
PMCPMC5444516
OpenAlexW2543248273

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.