Trial reportTransactions of the Royal Society of Tropical Medicine and Hygiene2016
Verbal autopsy-assigned causes of death among adults being investigated for TB in South Africa.
Trial report in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Are all tuberculosis deaths correctly attributed due to tuberculosis? Analysis of causes of death (COD) using verbal autopsy: A cross-sectional study in Puducherry.Journal of family medicine and primary care · 2025Article
- Social and demographic correlates of cardiovascular mortality in the Kassena-Nankana districts of Ghana: a verbal post-mortem analysis.International journal of epidemiology · 2022Article
- Comparison of the Causes of Death Identified Using Automated Verbal Autopsy and Complete Autopsy among Brought-in-Dead Cases at a Tertiary Hospital in Sub-Sahara Africa.Applied clinical informatics · 2022Article
- Burden of mortality from cancer among adults in Addis Ababa, Ethiopia, using verbal autopsy, 2007-2017.Ecancermedicalscience · 2022Article
- Mortality and risk of tuberculosis among people living with HIV in whom TB was initially ruled out.Scientific reports · 2020Article
- Unmasking the hidden tuberculosis mortality burden in a largeThe European respiratory journal · 2019Observational
- Article
- Completeness and reliability of mortality data in Viet Nam: Implications for the national routine health management information system.PloS one · 2018Article
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdults being investigated for TB in South Africa experience high mortality, yet causes of death (CoD) are not well defined. We determined CoD in this population using verbal autopsy (VA), and compared HIV- and TB-associated CoD using physician-certified verbal autopsy (PCVA) and InterVA-4 software.
methodsAll contactable consenting caregivers of participants who died during a trial comparing Xpert MTB/RIF to smear microscopy were interviewed using the WHO VA tool. CoD were assigned using PCVA and InterVA-4. Kappa statistic (K) and concordance correlation coefficient (CCC) were calculated for comparison.
resultsAmong 231 deaths, relatives of 137 deceased were interviewed. Of the 137 deceased 76 (55.4%) were males, median age 41 years (IQR 33-50). PCVA assigned 70 (51.1%) TB immediate CoD (44 [62.8%] pulmonary TB; 26 [37.1%] extra-pulmonary TB); 21 (15.3%) HIV/AIDS-related; and 46 (33.5%) other CoD. InterVA-4 assigned 48 (35.0%) TB deaths; 49 (35.7%) HIV/AIDS-related deaths; and 40 (29.1%) other CoD. Agreement between PCVA and InterVA-4 CoD was slight at individual level (K=0.20; 95% CI 0.10-0.30) and poor at population level (CCC 0.67; 95% CI 0.38-0.99).
conclusionsTB and HIV are leading CoD among adults being investigated for TB. PCVA and InterVA agreement at individual level was slight and poor at population level. VA methodology needs further development where TB and HIV are common.
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