ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2016
Latent Toxoplasma Infection and Higher Toxoplasma gondii Immunoglobulin G Levels Are Associated With Worse Neurocognitive Functioning in HIV-Infected Adults.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Soluble Biomarkers of Cognition and Depression in Adults with HIV Infection in the Combination Therapy Era.Current HIV/AIDS reports · 2021Review
- Epidemiology, Pathophysiology, Diagnosis, and Management of Cerebral Toxoplasmosis.Clinical microbiology reviews · 2021Review
- Review
- Impact of Latent Tuberculosis Infection on Neurocognitive Functioning and Inflammation in HIV-Infected and Uninfected South Indians.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Rosuvastatin reduced brain parasite burden in a chronic toxoplasmosisParasitology · 2020Article
- Altered Brain Function in Young HIV Patients with Syphilis Infection: A Voxel-Wise Degree Centrality Analysis.Infection and drug resistance · 2020Article
- Toxoplasma: Immunity and Pathogenesis.Current clinical microbiology reports · 2019Article
- Empiric neurocognitive performance profile discovery and interpretation in HIV infection.Journal of neurovirology · 2019Article
- Cognitive Impairment in Zambians With HIV Infection and Pulmonary Tuberculosis.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Genital HIV-1 Shedding With Dolutegravir (DTG) Plus Lamivudine (3TC) Dual Therapy.Journal of acquired immune deficiency syndromes (1999) · 2018Article
- Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bcACS infectious diseases · 2018Article
- Article
- Article
- Human Immunodeficiency Virus in the Brain-Culprit or Facilitator?Infectious diseases · 2018Review
- Neurosyphilis Increases Human Immunodeficiency Virus (HIV)-associated Central Nervous System Inflammation but Does Not Explain Cognitive Impairment in HIV-infected Individuals With Syphilis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection.Nature microbiology · 2017Article
- Downregulated IL-21 Response and T Follicular Helper Cell Exhaustion Correlate with Compromised CD8 T Cell Immunity during Chronic Toxoplasmosis.Frontiers in immunology · 2017Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHuman immunodeficiency virus (HIV)-associated neurocognitive disorders persist despite suppressive antiretroviral therapy (ART). Because latent Toxoplasma infection (LTI) may adversely impact brain function, we investigated its impact on neurocognitive impairment (NCI) in people living with HIV disease.
methodsTwo hundred sixty-three HIV-infected adults underwent comprehensive neurocognitive assessments and had anti-Toxoplasma gondii immunoglobulin G (anti-Toxo IgG) measured by qualitative and quantitative enzyme-linked immunosorbent assays.
resultsParticipants were mostly middle-aged white men who were taking ART (70%). LTI was detected in 30 (11.4%) participants and was associated with a significantly greater prevalence of global NCI (LTI positive [LTI
conclusionsIn this cross-sectional analysis, LTI was associated with NCI, especially in those with higher CD4
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