Evidence map›Paper›PMID 27793884›Full record

ReviewAnticancer research2016

Discovery of Anticancer Agents of Diverse Natural Origin.

A Douglas Kinghorn, Esperanza J Carcache DE Blanco, David M Lucas, H Liva Rakotondraibe, Jimmy Orjala, D Doel Soejarto, Nicholas H Oberlies, Cedric J Pearce, Mansukh C Wani, Brent R Stockwell and 7 more

Abstract readReview
In one paragraph

Review in Anticancer research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

  1. Review
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  8. On the Unknown Proteins of Eukaryotic Proteomes.Journal of molecular evolution · 2023
    Article
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  18. Bioactive small-molecule constituents of Lao plants.Journal of medicinal plant research · 2021
    Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

A Douglas KinghornCollege of Pharmacy, The Ohio State University, Columbus, OH, U.S.A. kinghorn.4@osu.edu.
Esperanza J Carcache DE BlancoCollege of Pharmacy, The Ohio State University, Columbus, OH, U.S.A.
David M LucasComprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A.
H Liva RakotondraibeCollege of Pharmacy, The Ohio State University, Columbus, OH, U.S.A.
Jimmy OrjalaCollege of Pharmacy, University of Illinois at Chicago, Chicago, IL, U.S.A.
D Doel SoejartoCollege of Pharmacy, University of Illinois at Chicago, Chicago, IL, U.S.A.
Nicholas H OberliesDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, U.S.A.
Cedric J PearceMycosynthetix, Inc., Hillsborough, NC, U.S.A.
Mansukh C WaniResearch Triangle Institute, Research Triangle Park, NC, U.S.A.
Brent R StockwellDepartment of Biological Sciences, Columbia University, New York, NY, U.S.A.
Joanna E BurdetteCollege of Pharmacy, University of Illinois at Chicago, Chicago, IL, U.S.A.
Steven M SwansonSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI, U.S.A.
James R FuchsCollege of Pharmacy, The Ohio State University, Columbus, OH, U.S.A.
Mitchell A PhelpsCollege of Pharmacy, The Ohio State University, Columbus, OH, U.S.A.
Lihui XuComprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A.
Xiaoli ZhangComprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A.
Young Yongchun ShenEisai Inc., Andover, MA, U.S.A.

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI JIMMY ORJALA · 2007 to 2026
$27.2M
Defining the functions and translational potential of ferroptosisR35CA209896 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI STOCKWELL, BRENT R. · 2016 to 2022
$6.5M
NCI NIH HHS P01 CA125066NCI NIH HHS P30 CA016058NCI NIH HHS R35 CA209896
6 · The paper itself

Abstract

Recent progress is described in an ongoing collaborative multidisciplinary research project directed towards the purification, structural characterization, chemical modification, and biological evaluation of new potential natural product anticancer agents obtained from a diverse group of organisms, comprising tropical plants, aquatic and terrestrial cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which initial extracts, chromatographic fractions, and purified isolated compounds of these acquisitions are tested. Several promising biologically active lead compounds from each major organism class investigated are described, and these may be seen to be representative of a very wide chemical diversity.

Indexed as

Drug DiscoveryAntineoplastic AgentsBiological ProductsHumansNeoplasmsAntineoplastic AgentsBiological ProductscyanobacteriafungiNatural productspotential anticancer activityreviewtropical plants

Identifiers

PMID27793884
PMCPMC5098703

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.