ArticleBiology open2016
Early molecular events during retinoic acid induced differentiation of neuromesodermal progenitors.
Article in Biology open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Early retinoic acid signaling organizes the body axis and defines domains for the forelimb and eye.Current topics in developmental biology · 2025Review
- A new paradigm for generating high-quality cardiac pacemaker cells from mouse pluripotent stem cells.Signal transduction and targeted therapy · 2024Article
- Retinoic acid, RARs and early development.Journal of molecular endocrinology · 2022Article
- Hinge point emergence in mammalian spinal neurulation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Shaping axial identity during human pluripotent stem cell differentiation to neural crest cells.Biochemical Society transactions · 2022Article
- Identification of downstream effectors of retinoic acid specifying the zebrafish pancreas by integrative genomics.Scientific reports · 2021Article
- Cell-to-cell heterogeneity in Sox2 and Bra expression guides progenitor motility and destiny.eLife · 2021Article
- Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization.JCI insight · 2021Article
- Getting in touch with your senses: Mechanisms specifying sensory interneurons in the dorsal spinal cord.WIREs mechanisms of disease · 2021Review
- Embryonal Neuromesodermal Progenitors for Caudal Central Nervous System and Tissue Development.Journal of Korean Neurosurgical Society · 2021Article
- A brief history of organoids.American journal of physiology. Cell physiology · 2020Review
- Discovery of genes required for body axis and limb formation by global identification of retinoic acid-regulated epigenetic marks.PLoS biology · 2020Article
- Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes.Journal of developmental biology · 2020Review
- Article
- New Insights into the Control of Cell Fate Choices and Differentiation by Retinoic Acid in Cranial, Axial and Caudal Structures.Biomolecules · 2019Review
- The transcription factor NKX1-2 promotes adipogenesis and may contribute to a balance between adipocyte and osteoblast differentiation.The Journal of biological chemistry · 2019Article
- Article
- Retinoic acid signaling pathways.Development (Cambridge, England) · 2019Review
- An epiblast stem cell-derived multipotent progenitor population for axial extension.Development (Cambridge, England) · 2019Article
- Transcriptome analysis of Xenopus orofacial tissues deficient in retinoic acid receptor function.BMC genomics · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Bipotent neuromesodermal progenitors (NMPs) residing in the caudal epiblast drive coordinated body axis extension by generating both posterior neuroectoderm and presomitic mesoderm. Retinoic acid (RA) is required for body axis extension, however the early molecular response to RA signaling is poorly defined, as is its relationship to NMP biology. As endogenous RA is first seen near the time when NMPs appear, we used WNT/FGF agonists to differentiate embryonic stem cells to NMPs which were then treated with a short 2-h pulse of 25 nM RA or 1 µM RA followed by RNA-seq transcriptome analysis. Differential expression analysis of this dataset indicated that treatment with 25 nM RA, but not 1 µM RA, provided physiologically relevant findings. The 25 nM RA dataset yielded a cohort of previously known caudal RA target genes including Fgf8 (repressed) and Sox2 (activated), plus novel early RA signaling targets with nearby conserved RA response elements. Importantly, validation of top-ranked genes in vivo using RA-deficient Raldh2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.