ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2017
Glucose level decline precedes dementia in elderly African Americans with diabetes.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Associations of Mid- and Late-Life Fasting Blood Glucose Levels With Dementia Risk Among Patients With Diabetes: Framingham Heart Study.European journal of neurology · 2025Article
- Assessing Risk Factors for Cognitive Decline Using Electronic Health Record Data: A Scoping Review.Research square · 2024Article
- The relationship between diabetes and the dementia risk: a meta-analysis.Diabetology & metabolic syndrome · 2024Review
- Article
- Hypericin as a potential drug for treating Alzheimer's disease and type 2 diabetes with a view to drug repositioning.CNS neuroscience & therapeutics · 2023Article
- Association between cardiovascular diseases and dementia among various age groups: a population-based cohort study in older adults.Scientific reports · 2023Article
- Altered cortical thickness, degree centrality, and functional connectivity in middle-age type 2 diabetes mellitus.Frontiers in neurology · 2022Article
- Changes of glucose levels precede dementia in African-Americans with diabetes but not in Caucasians.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Article
- Letter.Alzheimer's & dementia (Amsterdam, Netherlands) · 2017Article
- Population Neuroscience: Dementia Epidemiology Serving Precision Medicine and Population Health.Alzheimer disease and associated disordersArticle
- The Potential of 'Omics to Link Lipid Metabolism and Genetic and Comorbidity Risk Factors of Alzheimer's Disease in African Americans.Advances in experimental medicine and biologyReview
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
introductionHigh blood glucose levels may be responsible for the increased risk for dementia in diabetic patients.
methodsA secondary data analysis merging electronic medical records (EMRs) with data collected from the Indianapolis-Ibadan Dementia project (IIDP). Of the enrolled 4105 African Americans, 3778 were identified in the EMR. Study endpoints were dementia, mild cognitive impairment (MCI), or normal cognition. Repeated serum glucose measurements were used as the outcome variables.
resultsDiabetic participants who developed incident dementia had a significant decrease in serum glucose levels in the years preceding the diagnosis compared to the participants with normal cognition (P = .0002). They also had significantly higher glucose levels up to 9 years before the dementia diagnosis (P = .0367). DISCUSSION: High glucose levels followed by a decline occurring years before diagnosis in African American participants with diabetes may represent a powerful presymptomatic metabolic indicator of dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.