ArticleMatrix biology : journal of the International Society for Matrix Biology2017
Extracellular matrix downregulation in the Drosophila heart preserves contractile function and improves lifespan.
Article in Matrix biology : journal of the International Society for Matrix Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- The Extracellular Matrix Proteins Pericardin and Lonely Heart Modulate the Directionality of Heart Contractions in Infected Mosquitoes.Archives of insect biochemistry and physiology · 2026Article
- A short-lived fish with long-lasting effects: hallmarks of aging inFrontiers in aging · 2025Review
- Cardiac function and extracellular matrix morphology are altered by chronic high fat diet in Drosophila larvae.PloS one · 2025Article
- Genome-Wide Expression Profiling and Phenotypic Analysis of Downstream Targets Identify the Fox Transcription Factor Jumeau as a Master Regulator of Cardiac Progenitor Cell Division.International journal of molecular sciences · 2024Article
- How does a fly die? Insights into ageing from the pathophysiology of Drosophila mortality.GeroScience · 2024Review
- MBNL2 promotes aging-related cardiac fibrosis via inhibited SUMOylation of Krüppel-like factor4.iScience · 2024Article
- The BKPhysiological reports · 2024Article
- Signaling circuits and the apical extracellular matrix in aging: connections identified in the nematodeAmerican journal of physiology. Cell physiology · 2023Review
- Identification of unique α4 chain structure and conserved antiangiogenic activity of α3NC1 type IV collagen in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Ten Years of Extracellular Matrix Proteomics: Accomplishments, Challenges, and Future Perspectives.Molecular & cellular proteomics : MCP · 2023Review
- Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs.Nature aging · 2023Article
- The role of basement membranes in cardiac biology and disease.Bioscience reports · 2021Review
- Macrophages and Their Organ Locations Shape Each Other in Development and Homeostasis - AFrontiers in cell and developmental biology · 2021Review
- Ageing, sex, and cardioprotection.British journal of pharmacology · 2020Review
- Mechanotranduction Pathways in the Regulation of Mitochondrial Homeostasis in Cardiomyocytes.Frontiers in cell and developmental biology · 2020Review
- Article
- As time flies by: Investigating cardiac aging in the short-lived Drosophila model.Biochimica et biophysica acta. Molecular basis of disease · 2019Review
- Organelle aging: Lessons from model organisms.Journal of genetics and genomics = Yi chuan xue bao · 2019Review
- The impact of SPARC on age-related cardiac dysfunction and fibrosis in Drosophila.Experimental gerontology · 2018Article
- Distinct domains in the matricellular protein Lonely heart are crucial for cardiac extracellular matrix formation and heart function inThe Journal of biological chemistry · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Aging is associated with extensive remodeling of the heart, including basement membrane (BM) components that surround cardiomyocytes. Remodeling is thought to impair cardiac mechanotransduction, but the contribution of specific BM components to age-related lateral communication between cardiomyocytes is unclear. Using a genetically tractable, rapidly aging model with sufficient cardiac genetic homology and morphology, e.g. Drosophila melanogaster, we observed differential regulation of BM collagens between laboratory strains, correlating with changes in muscle physiology leading to cardiac dysfunction. Therefore, we sought to understand the extent to which BM proteins modulate contractile function during aging. Cardiac-restricted knockdown of ECM genes Pericardin, Laminin A, and Viking in Drosophila prevented age-associated heart tube restriction and increased contractility, even under viscous load. Most notably, reduction of Laminin A expression correlated with an overall preservation of contractile velocity with age and extension of organismal lifespan. Global heterozygous knockdown confirmed these data, which provides new evidence of a direct link between BM homeostasis, contractility, and maintenance of lifespan.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.