Evidence map›Paper›PMID 27793593›Full record

ArticleImmunity2016

Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells.

Andrew Jones, Jessica Bourque, Lindsey Kuehm, Adeleye Opejin, Ryan M Teague, Cindy Gross, Daniel Hawiger

Open access · bronzeAbstract read
In one paragraph

Article in Immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 144 citations in OpenAlex.

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  6. The DC1 conundrum: Do type I dendritic cells make or break allograft tolerance?American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Review
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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Commented on by
    BTLA2016
5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Andrew JonesDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
Jessica BourqueDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
Lindsey KuehmDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
Adeleye OpejinDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
Ryan M TeagueDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
Cindy GrossDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
Daniel HawigerDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA. Electronic address: dhawiger@slu.edu.
Saint Louis University · US

Funding

Functions of Hopx in immune tolerance in a model of Multiple SclerosisR01AI113903 · NIAID · SAINT LOUIS UNIVERSITY · PI HAWIGER, DANIEL · 2014 to 2018
$1.9M
NIAID NIH HHS R01 AI113903
6 · The paper itself

Abstract

Dendritic cells (DCs) initiate immunity and also antigen-specific tolerance mediated by extrathymic regulatory T (Treg) cells, yet it remains unclear how DCs regulate induction of such tolerance. Here, we report that efficient induction of Treg cells was instructed by BTLA

Indexed as

Adoptive TransferAnimalsDendritic CellsEncephalomyelitis, Autoimmune, ExperimentalFlow CytometryImmune ToleranceImmunoblottingLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutReal-Time Polymerase Chain ReactionReceptors, ImmunologicReceptors, Tumor Necrosis Factor, Member 14T-Lymphocytes, RegulatoryBTLA protein, mouseReceptors, ImmunologicReceptors, Tumor Necrosis Factor, Member 14Tnfrsf14 protein, mouse

Identifiers

PMID27793593
PMCPMC5112132
OpenAlexW2535141202

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.