ArticleBMC veterinary research2016
Measurement of serum C-reactive protein concentration for discriminating between suppurative arthritis and osteoarthritis in dogs.
Article in BMC veterinary research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Postoperative kinetics of point-of-care C-reactive protein versus total white blood cell count after tibial plateau leveling osteotomy in dogs.Veterinary world · 2026Article
- Phenotypic Differences in Inflammatory, Metabolic, and Biochemical Biomarkers in Dogs with Osteoarthritis According to Body Condition and Sex.Animals : an open access journal from MDPI · 2026Article
- Advances in the pathology and treatment of osteoarthritis.Journal of advanced research · 2025Review
- The effects of torula yeast as a protein source on apparent total tract digestibility, inflammatory markers, and fecal microbiota dysbiosis index in Labrador Retrievers with chronically poor stool quality.Journal of animal science · 2024Article
- Development and clinical evaluation of a quantitative fluorescent immunoassay for detecting canine CRP.International journal of veterinary science and medicine · 2023Article
- Prospective evaluation of novel biomarkers of acute kidney injury in dogs following cardiac surgery under cardiopulmonary bypass.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2022Article
- Effect of Leukoreduced Platelet Rich Plasma on Intra-Articular Pro-Inflammatory Cytokines in a Canine Pilot Study.Animals : an open access journal from MDPI · 2022Article
- Development of canine C-reactive protein assays.Acta veterinaria Scandinavica · 2020Article
- Gut Microbiome of Healthy and Arthritic Dogs.Veterinary sciences · 2020Article
- Clinical utility of currently available biomarkers in inflammatory enteropathies of dogs.Journal of veterinary internal medicine · 2018Review
- Hematologic and serologic status of military working dogs given standard diet containing natural botanical supplements.Toxicology reports · 2018Article
- Serum C-reactive protein concentrations in Nova Scotia Duck Tolling Retrievers with immune-mediated rheumatic disease.Acta veterinaria Scandinavica · 2017Article
- A blinded, placebo-controlled study on the clinical effects of vitamin E supplementation in dogs with osteoarthritis.Journal of veterinary internal medicineArticle
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIn a dog with joint pain, it is important to determine whether it has suppurative joint disease, characterized by exudation of neutrophils in the synovial fluid, or not, as this affects choice of diagnostic tests and treatments. The aim of this study was to evaluate whether measurement of serum C-reactive protein (CRP) concentration could be used to discriminate between dogs with suppurative arthritis and osteoarthritis (OA). Furthermore, the concentrations of serum and synovial fluid interleukin (IL) 6 concentrations were measured in dogs with joint disease and in healthy dogs, and were correlated to serum CRP concentrations.
methodsDogs with joint pain were enrolled prospectively and were classified to have suppurative arthritis or OA based on synovial fluid analysis and radiographic/arthroscopic findings. Healthy Beagles were enrolled as a comparative group. CRP and IL-6 concentrations were measured with canine-specific immunoassays. The performance of CRP concentration in discriminating between dogs with suppurative arthritis and OA was evaluated using a previously established clinical decision limit for CRP (20 mg/l), and by receiver operator characteristic (ROC) curve and logistic regression analysis. Comparisons of CRP and IL-6 concentrations between groups were performed using t-tests, and correlations by Spearman rank correlation coefficients.
resultsSamples were obtained from 31 dogs with suppurative arthritis, 34 dogs with OA, and 17 healthy dogs. Sixty-two out of 65 dogs with joint disease were correctly classified using the clinical decision limit for CRP. Evaluation of ROC curve and regression analysis indicated that serum CRP concentrations could discriminate between suppurative arthritis and OA. Dogs with suppurative arthritis had higher serum CRP and serum and synovial fluid IL-6 concentrations compared to dogs with OA (p < 0.001). Dogs with OA had higher synovial fluid IL-6 concentrations (p < 0.001), but not higher serum CRP (p = 0.29) or serum IL-6 (p = 0.07) concentrations, compared to healthy dogs. There was a positive correlation between synovial fluid IL-6 and serum CRP concentrations (r
conclusionCRP concentration was found to discriminate well between dogs with suppurative arthritis and OA.
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