ArticleJournal of neuroengineering and rehabilitation2016
Global cognitive function and processing speed are associated with gait and balance dysfunction in Parkinson's disease.
Article in Journal of neuroengineering and rehabilitation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04730466 (Validation of Cognitive Rehabilitation as a Balance Rehabilitation Strategy in Patients With Parkinson's Disease), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Validation of Cognitive Rehabilitation as a Balance Rehabilitation Strategy in Patients With Parkinson's Disease: Study Protocol for a Randomized Controlled Trial
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuroimaging and cognitive correlates of postural control in Parkinson's disease: a systematic review.Journal of neuroengineering and rehabilitation · 2025Pooled it
- Motor-Derived Digital Biomarkers for Identifying Low-MoCA Status in People with Parkinson's Disease.Sensors (Basel, Switzerland) · 2026Article
- Influence of cognitive function on postural control in physically independent older women: a time and time-frequency domain analysis.BMC geriatrics · 2026Article
- Brain age gap as a predictive biomarker that links aging, lifestyle, and neuropsychiatric health.Communications medicine · 2025Article
- Exercise Specialists' Evaluation of Robot-Led Rehabilitative Exercise for People with Parkinson's Disease.Healthcare (Basel, Switzerland) · 2025Article
- Timed 25-foot walk test is independently associated with cognitive function in multiple sclerosis: a cross-sectional study.European journal of medical research · 2025Article
- Gait and balance dysfunction are associated with cognitive performance only in men with Parkinson's disease.Clinical parkinsonism & related disorders · 2025Article
- Differential cognitive functioning in the digital clock drawing test in AD-MCI and PD-MCI populations.Frontiers in neuroscience · 2025Article
- Changes in postural stability after cerebrospinal fluid tap test in patients with idiopathic normal pressure hydrocephalus.Frontiers in neurology · 2024Article
- Commercial symptom monitoring devices in Parkinson's disease: benefits, limitations, and trends.Frontiers in neurology · 2024Review
- Effect of musical cues on gait in individuals with Parkinson disease with comorbid dementia.Gait & posture · 2024Article
- Exploring mobility dysfunction in people with and without impaired cognition in Parkinson disease.Parkinsonism & related disorders · 2023Article
- Immersive Virtual Reality Reaction Time Test and Relationship with the Risk of Falling in Parkinson's Disease.Sensors (Basel, Switzerland) · 2023Article
- Parkinson's Disease and Diabetes Mellitus: Individual and Combined Effects on Motor, Cognitive, and Psychosocial Functions.Healthcare (Basel, Switzerland) · 2023Article
- Associations of Word Memory, Verbal Fluency, Processing Speed, and Crystallized Cognitive Ability With One-Legged Balance Performance in Mid- and Later Life.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- The emerging postural instability phenotype in idiopathic Parkinson disease.NPJ Parkinson's disease · 2022Article
- Cortical oscillatory dysfunction in Parkinson disease during movement activation and inhibition.PloS one · 2022Article
- Recent Trends and Practices Toward Assessment and Rehabilitation of Neurodegenerative Disorders: Insights From Human Gait.Frontiers in neuroscience · 2022Review
- Wearable Devices for Physical Activity and Healthcare Monitoring in Elderly People: A Critical Review.Geriatrics (Basel, Switzerland) · 2021Review
- Perceived walking difficulties in Parkinson's disease - predictors and changes over time.BMC geriatrics · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundOur primary objective was to determine the relationship between global cognitive function and specific domains of gait and balance in a cohort of Parkinson's disease (PD) subjects. In a secondary analysis, we determined whether specific cognitive domains correlated with gait and balance performance.
methodsFourteen PD subjects (mean age 61.1 ± 7.8 years) were recruited from the Rush University Medical Center Movement Disorders clinic. Subjects underwent clinical assessment using the motor subsection of the Unified Parkinson's Disease Rating Scale (UPDRS) followed by quantitative gait and balance assessments using the APDM Mobility Lab™ system (Mobility Lab, APDM Inc., Portland, OR). Subjects completed global cognitive testing using the Mattis Dementia Rating Scale (MDRS) as well as domain specific cognitive measures. Spearman's rho was used to assess correlations between cognitive measures and gait and balance function, with False Discovery Rate (FDR) correction for multiple comparisons.
resultsGlobal cognitive function had the strongest correlation with stride velocity (r = 0.816, p = 0.001), turn duration (r = -0.806, p = 0.001), number of steps to turn (r = -0.830, p = 0.001), and mean velocity of postural sway in the medio-lateral direction (r = -0.726, p = 0.005). A significant correlation was found between processing speed and two turning measures (turn duration, r = -0.884, p = 0.001; number of steps to turn, r = -0.954, p < 0.001), but no other associations were found between specific cognitive domains and gait domains.
conclusionsThis pilot study provides preliminary data regarding the association between global cognitive function and pace-related measures of gait, turning, and postural sway. Furthermore, reduced processing speed was found to be associated with difficulty in performing turns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.