ArticleCardiovascular diabetology2016
Metabolic syndrome is independently associated with increased 20-year mortality in patients with stable coronary artery disease.
Article in Cardiovascular diabetology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association between handgrip strength and metabolic syndrome: A meta-analysis and systematic review.Frontiers in nutrition · 2022Pooled it
- High intensity interval training exercise-induced physiological changes and their potential influence on metabolic syndrome clinical biomarkers: a meta-analysis.BMC endocrine disorders · 2020Pooled it
- The effect of exercise training on clinical outcomes in patients with the metabolic syndrome: a systematic review and meta-analysis.Cardiovascular diabetology · 2017Pooled it
- Effect of a Low-Moderate Exercise Program on Dysmetabolism in Older Adults: Results of a Randomized Controlled Trial.Nutrients · 2022Trial
- Visceral Adiposity and Markers of Relative Sarcopenia in Young Adults with Normal Weight Obesity: Gender Differences.Healthcare (Basel, Switzerland) · 2026Article
- Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) and mortality among survivors of liver cirrhosis: a prospective cohort study.Nutrition journal · 2025Article
- Influence of Lifestyle Factors on Metabolic Syndrome in Psychiatric Patients Attending a Community Mental Health Setting: A Cross-sectional Study.Indian journal of psychological medicine · 2024Article
- Assessing the generalisability of the psychosis metabolic risk calculator (PsyMetRiC) for young people with first-episode psychosis with validation in a Hong Kong Chinese Han population: a 4-year follow-up study.The Lancet regional health. Western Pacific · 2024Article
- Ceramides and metabolic profiles of patients with acute coronary disease: a cross-sectional study.Frontiers in physiology · 2023Article
- The psychosis metabolic risk calculator (PsyMetRiC) for young people with psychosis: International external validation and site-specific recalibration in two independent European samples.The Lancet regional health. Europe · 2022Article
- Relationship between Metabolic Syndrome and Clinical Outcome in Patients Treated with Drug-Eluting Stenting after Rotational Atherectomy for Complex Calcified Coronary Lesions.Journal of clinical medicine · 2022Article
- Sex-specific prevalence of metabolic syndrome in older adults: results from the Neyshabur longitudinal study on aging, Iran.Journal of diabetes and metabolic disorders · 2022Article
- Machine learning-aided risk prediction for metabolic syndrome based on 3 years study.Scientific reports · 2022Article
- Impaired Sensitivity to Thyroid Hormones Is Associated With Elevated Blood Glucose in Coronary Heart Disease.Frontiers in endocrinology · 2022Article
- Association of dyslipidemia, diabetes and metabolic syndrome with serum ferritin levels: a middle eastern population-based cross-sectional study.Scientific reports · 2021Article
- Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats.Oxidative medicine and cellular longevity · 2021Article
- Association of obesity, visceral adiposity, and sarcopenia with an increased risk of metabolic syndrome: A retrospective study.PloS one · 2021Article
- Association between sarcopenia level and metabolic syndrome.PloS one · 2021Article
- An Approach to Early Detection of Metabolic Syndrome through Non-Invasive Methods in Obese Children.Children (Basel, Switzerland) · 2020Article
- Risk for cardiovascular disease associated with metabolic syndrome and its components: a 13-year prospective study in the RIVANA cohort.Cardiovascular diabetology · 2020Article
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9 authors.
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Abstract
backgroundData regarding long-term association of metabolic syndrome (MetS) with adverse outcomes are conflicting. We aim to determine the independent association of MetS (based on its different definitions) with 20 year all-cause mortality among patients with stable coronary artery disease (CAD).
methodsOur study comprised 15,524 patients who were enrolled in the Bezafibrate Infarction Prevention registry between February 1, 1990, and October 31, 1992, and subsequently followed-up for the long-term mortality through December 31, 2014. MetS was defined according to two definitions: The International Diabetes Federation (IDF); and the National Cholesterol Education Program-Third Adult Treatment Panel (NCEP).
resultsAccording to the IDF criteria 2122 (14%) patients had MetS, whereas according to the NCEP definition 7446 (48%) patients had MetS. Kaplan-Meier survival analysis showed that all-cause mortality was significantly higher among patients with MetS defined by both the IDF (67 vs. 61%; log rank-p < 0.001) as well as NCEP (67 vs. 54%; log rank-p < 0.001) criteria. Multivariate adjusted mortality risk was 17% greater [Hazard Ratio (HR) 1.17; 95% Confidence Interval (CI) 1.07-1.28] in patients with MetS according to IDF and 21% (HR 1.21; 95% CI 1.13-1.29) using the NCEP definition. Subgroup analysis demonstrated that long-term increased mortality risk associated with MetS was consistent among most clinical subgroups excepted patients with renal failure (p value for interaction < 0.05).
conclusionsMetabolic syndrome is independently associated with an increased 20-year all-cause mortality risk among patients with stable CAD. This association was consistent when either the IDF or NCEP definitions were used. Trial registration retrospective registered.
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