ArticleBMC complementary and alternative medicine2016
Sarcandra glabra (Caoshanhu) protects mesenchymal stem cells from oxidative stress: a bioevaluation and mechanistic chemistry.
Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Anti-inflammatory and antioxidant activity of ursolic acid: a systematic review and meta-analysis.Frontiers in pharmacology · 2023Pooled it
- Antioxidant Chemistry of Phenolics in Chinese Herbal Medicines: A Holism-Based Review.Chemistry & biodiversity · 2026Review
- Review
- Genomic insights into the mitochondrial architecture ofFrontiers in plant science · 2026Article
- Multi-Component Characterization and Quality Evaluation Strategy ofMolecules (Basel, Switzerland) · 2025Article
- Astilbin improves the therapeutic effects of mesenchymal stem cells in AKI-CKD mice by regulating macrophage polarization through PTGS2-mediated pathway.Stem cell research & therapy · 2024Article
- A comprehensive review on the chemical constituents, sesquiterpenoid biosynthesis and biological activities of Sarcandra glabra.Natural products and bioprospecting · 2023Review
- Polyelectrolyte Chondroitin Sulfate Microgels as a Carrier Material for Rosmarinic Acid and Their Antioxidant Ability.Polymers · 2022Article
- Review
- Assessment of the Potential ofFrontiers in pharmacology · 2022Article
- Consequences of LED Lights on Root Morphological Traits and Compounds Accumulation inInternational journal of molecular sciences · 2021Article
- Evaluation of antioxidant property of heat shock protein 90 from duck muscle.Animal bioscience · 2021Article
- Rosmarinic Acid Regulates Microglial M1/M2 Polarization via the PDPK1/Akt/HIF Pathway Under Conditions of Neuroinflammation.Inflammation · 2021Article
- The Traditional Uses, Phytochemistry and Pharmacology ofFrontiers in pharmacology · 2021Review
- Transcriptomic and metabolomic profiling reveals the effect of LED light quality on morphological traits, and phenylpropanoid-derived compounds accumulation in Sarcandra glabra seedlings.BMC plant biology · 2020Article
- Biologically Active Compounds of Plants: Structure-Related Antioxidant, Microbiological and Cytotoxic Activity of Selected Carboxylic Acids.Materials (Basel, Switzerland) · 2020Review
- Antioxidant Potential of Psychotropic Drugs: From Clinical Evidence to In Vitro and In Vivo Assessment and toward a New Challenge for in Silico Molecular Design.Antioxidants (Basel, Switzerland) · 2020Review
- Inhibitory Effect and Mechanism of Action of Quercetin and Quercetin Diels-AlderAntioxidants (Basel, Switzerland) · 2020Article
- Simultaneous Study of Anti-Ferroptosis and Antioxidant Mechanisms of Butein and (Molecules (Basel, Switzerland) · 2020Article
- Antioxidant and Cytoprotective effects of Pyrola decorata H. Andres and its five phenolic components.BMC complementary and alternative medicine · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSarcandra glabra (Caoshanhu) is a traditional Chinese herbal medicine used for treating various oxidative-stressed diseases. The present work evaluated its protective effect on mesenchymal stem cells (MSCs) from oxidative stress and then discussed possible mechanisms underlying this observation.
methodsEthanolic extract of S. glabra (ESG) was investigated by chemical methods for its content of total phenolics, rosmarinic acid, and astilbin. ESG, along with rosmarinic acid and astilbin, was investigated for the effect on the viability of Fenton-treated MSCs using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl (MTT) assay. The observed cell protective effect was further explored by mechanistic chemistry using various antioxidant assays, including DNA protection, •OH-scavenging, •O
resultsAnalysis of ESG revealed a content of 46.31 ± 0.56 mg quercetin/g total phenolics, 0.78 ± 0.01 % rosmarinic acid, and 3.37 ± 0.01 % astilbin. Results from the MTT assay revealed that three compounds (rosmarinic acid>astilbin>ESG) could effectively increase the survival of Fenton-treated MSCs. Similarly, in •O
conclusionS. glabra can prevent MSCs from •OH-induced oxidative stress. Such protective effect can be attributed to its antioxidant ability and the presence of two kinds of phytophenols, i.e. caffeoyl derivatives and flavonoids. As the respective representatives of caffeoyl derivatives and flavonoids, rosmarinic acid and astilbin may exert the antioxidant action via direct ROS-scavenging and indirect ROS-scavenging (i.e. Fe
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