Evidence map›Paper›PMID 27793009›Full record

SynthesisOncotarget2017

The changing characteristics and molecular profiles of papillary thyroid carcinoma over time: a systematic review.

Huy Gia Vuong, Ahmed M A Altibi, Amr Hesham Abdelhamid, Phuong Uyen Duong Ngoc, Vo Duy Quan, Mohamed Yousef Tantawi, Mohamed Elfil, Tran Le Huy Vu, Ahmed Elgebaly, Naoki Oishi and 5 more

Open access · diamondAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 8 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 8 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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  14. Clinicopathological Implications of theFrontiers in medicine · 2022
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  18. BRAFJournal of cancer research and clinical oncology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 5 countries.

Huy Gia VuongDepartment of Pathology, University of Yamanashi, Yamanashi, Japan.
Ahmed M A AltibiFaculty of Medicine, University of Jordan, Amman, Jordan.
Amr Hesham AbdelhamidFaculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt.
Phuong Uyen Duong NgocPham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.
Vo Duy QuanUniversity of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.
Mohamed Yousef TantawiFaculty of Medicine, Zagazig University, Zagazig, Egypt.
Mohamed ElfilFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Tran Le Huy VuUniversity of California, Los Angeles, CA, USA.
Ahmed ElgebalyFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Naoki OishiDepartment of Pathology, University of Yamanashi, Yamanashi, Japan.
Tadao NakazawaDepartment of Pathology, University of Yamanashi, Yamanashi, Japan.
Kenji HirayamaDepartment of Immunogenetics, Institute of Tropical Medicine, Leading Graduate School Program, and Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto, Nagasaki, Japan.
Ryohei KatohDepartment of Pathology, University of Yamanashi, Yamanashi, Japan.
Nguyen Tien HuyDepartment of Clinical Product Development, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Tetsuo KondoDepartment of Pathology, University of Yamanashi, Yamanashi, Japan.
University of Yamanashi · JPNagasaki University · JPAl-Azhar University · EGAlexandria University · EGCho Ray Hospital · VNHo Chi Minh City Medicine and Pharmacy University · VNMenoufia University · EGPham Ngoc Thach University of Medicine · VNUniversity of Jordan · JOZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe genetic alterations of papillary thyroid carcinoma (PTC) have been reported to change over the past few decades. We performed this systematic review to further examine the trends and modifications of patient demographic, clinicopathological features and molecular profiles of PTC over time.

methodsA literature search was performed within six electronic databases to identify relevant articles. The inclusion criteria were published studies investigating BRAF mutations, RET/PTC rearrangements or RAS mutations in PTCs or classical PTCs. Two teams of reviewers independently screened titles and abstracts of all articles. Full texts of potential articles were read and extracted data were listed and stratified into an excel file according to country, city, institution, and surgical time period. Student t test and Pearson Chi-square were used to analyze the trends of demographic and clinicopathological features of PTC patients and the prevalence of each genetic alteration in individual institutions.

resultsFrom 3139 articles, we included 16 articles for final analysis. Our results showed an increasing trend of BRAF and a decreasing trend of RET/PTC prevalence over time in PTCs and classical PTCs, accompanied by an older age of PTC patients, an increase in proportion of PTMC and less aggressive behaviours of tumours.

conclusionsThe demographic and clinicopathological characteristics and molecular profile of PTCs have been changing over the past few decades. These modifications suggest changes in etiologies and risk factors of thyroid cancer that influence the tumorigenesis of PTCs.

Indexed as

AdultBiomarkers, TumorCarcinoma, PapillaryChi-Square DistributionFemaleGene RearrangementGenes, rasGenetic Predisposition to DiseaseHumansMaleMiddle AgedMutationPhenotypeProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-retRisk FactorsBiomarkers, TumorBRAF protein, humanProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-retRET protein, humanBRAFpapillaryRASRET/PTCthyroid carcinoma

Identifiers

PMID27793009
PMCPMC5354688
OpenAlexW2533015582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.