Evidence map›Paper›PMID 27792970›Full record

ArticleJournal of affective disorders2017

An actigraphy study investigating sleep in bipolar I patients, unaffected siblings and controls.

Sanne Verkooijen, Annet H van Bergen, Stefan E Knapen, Annabel Vreeker, Lucija Abramovic, Lucia Pagani, Yoon Jung, Rixt Riemersma-van der Lek, Robert A Schoevers, Joseph S Takahashi and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Evaluating endophenotypes for bipolar disorder.International journal of bipolar disorders · 2021
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Sanne VerkooijenDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: S.Verkooijen@umcutrecht.nl.
Annet H van BergenDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Stefan E KnapenDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Annabel VreekerDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Netherlands Institute of Mental Health and Addiction (Trimbos Institute), Drug Information and Monitoring System, Department of Drug Monitoring, Utrecht, The Netherlands; Department of Psychology, Leiden University, Leiden, The Netherlands.
Lucija AbramovicDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Lucia PaganiDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yoon JungCenter for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, CA, USA.
Rixt Riemersma-van der LekDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Lentis FACT, Winschoten, The Netherlands.
Robert A SchoeversDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Joseph S TakahashiDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
René S KahnDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Marco P M BoksDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Roel A OphoffDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, CA, USA.
University Medical Center Utrecht · NLThe University of Texas Southwestern Medical Center · USUniversity Medical Center Groningen · NLUniversity of California, Los Angeles · USLeiden University · NLUniversity of Groningen · NL

Funding

Genomic Studies of Bipolar Disorder in a Large Cohort from The NetherlandsR01MH090553 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OPHOFF, ROEL A · 2010 to 2014
$6.0M
NIMH NIH HHS R01 MH090553
6 · The paper itself

Abstract

objectivesDisturbances in sleep and waking patterns are highly prevalent during mood episodes in bipolar disorder. The question remains whether these disturbances persist during phases of euthymia and whether they are heritable traits of bipolar disorder. The current study investigates objective sleep measures in a large sample of bipolar I patients, non-affected siblings and controls.

methodsA total of 107 bipolar disorder I patients, 74 non-affected siblings, and 80 controls were included. Sleep was measured with actigraphy over the course of 14 days. Seven sleep parameters were analyzed for group differences and their relationship with age at onset, number of episodes and psychotic symptoms using linear mixed model analysis to account for family dependencies.

resultsPatients had a longer sleep duration and later time of sleep offset compared to the non-affected siblings but these differences were entirely attributable to differences in mood symptoms. We found no difference between patients and controls or siblings and controls when the analyses were restricted to euthymic patients. None of the bipolar illness characteristics were associated with sleep. LIMITATIONS: Medication use was not taken into account which may have influenced our findings and controls were younger compared to non-affected siblings.

conclusionsIn the largest study to date, our findings suggest that recovered bipolar I patients and their siblings do not experience clinically significant sleep disturbances. Sleep disturbances are primarily a reflection of current mood state, but are unrelated to the course of the disorder.

Indexed as

SleepActigraphyAdultAffectBipolar DisorderCase-Control StudiesFemaleHumansLinear ModelsMaleMiddle AgedPolysomnographySiblingsSleep Wake DisordersActigraphyBipolar disorderSleep disturbances

Identifiers

PMID27792970
PMCPMC5154955
OpenAlexW2531008970

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.